Short course · WHO IMCI

The sick child: IMCI in practice

Integrated Management of Childhood Illness (IMCI) gives first-level health workers one simple routine for every sick child: check for danger signs, ask about the main symptoms, classify by colour, treat, counsel and follow up. This course works through the WHO IMCI chart booklet (2014) for children aged 2 months up to 5 years and for young infants up to 2 months, updated with the WHO 2024 recommendations on serious bacterial infection in young infants and the WHO HIV guidelines, with cases from a busy clinic.

6 lessonsabout 240 minutes of reading
4 CPD hoursself-declared learning time
15-question quizpass mark 12
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Course objectives
  • Check every sick child for general danger signs and act on them.
  • Assess and classify cough, diarrhoea and fever using the IMCI colour-coded chart, and link fever to malaria testing and treatment.
  • Give the right home treatment: amoxicillin, ORS and zinc, antimalarials, vitamin A, iron.
  • Check for acute malnutrition and anaemia, assess feeding and counsel the carer using the IMCI feeding recommendations, and plan follow-up.
  • Assess and classify the sick young infant up to 2 months, and give the HIV-exposed infant prophylaxis, testing and follow-up.
Lesson 1 of 6 · about 25 minutes

The IMCI approach and general danger signs

By the end of this lesson you can
  • Describe the IMCI case-management process and its colour coding.
  • Check for the general danger signs and know what to do when one is present.

Most children who die before their fifth birthday die of a few common illnesses, often more than one at a time: pneumonia, diarrhoea, malaria, measles and malnutrition. IMCI was designed so that a health worker with a chart can find all of a child's problems at one visit, rather than treating only the one the carer mentions.

Two age groupsInfants from birth up to 2 months have their own chart because their signs of serious illness are different. Lessons 1 to 5 cover children aged 2 months up to 5 years; lesson 6 covers young infants.

The routine

  1. Ask what the child's problems are. Is this a first visit or a follow-up for this problem?
  2. Check for general danger signs.
  3. Ask about the main symptoms: cough or difficult breathing, diarrhoea, fever, ear problem.
  4. Check for acute malnutrition and anaemia, HIV status, immunisation and feeding.
  5. Classify each problem, identify treatment, treat, counsel the carer and plan follow-up.
ColourMeansTypical action
PinkSevere classificationPre-referral treatment and urgent referral
YellowNeeds specific treatmentTreat at the clinic or at home, follow up
GreenHome careAdvice on home care and when to return

General danger signs

  • Not able to drink or breastfeed.
  • Vomits everything.
  • Has had convulsions in this illness.
  • Lethargic or unconscious.
  • Convulsing now.
Any danger signA child with any danger sign needs URGENT attention. Complete the assessment quickly, give pre-referral treatment straight away (such as diazepam if convulsing, treatment to prevent low blood sugar, first doses of antibiotic or antimalarial as the chart says) and keep the child warm. Do not let the assessment delay referral.

Preventing low blood sugar

If the child can breastfeed, ask the mother to breastfeed. If not, but the child can swallow, give expressed breast milk or a breast-milk substitute, or sugar water (4 level teaspoons of sugar in a 200 mL cup of clean water): 30 to 50 mL before departure. If the child cannot swallow and you are trained, give 50 mL by nasogastric tube.

Case: A crowded morning

A mother brings her 2-year-old with fever for 2 days. While you wait, she tells you the child vomited after every drink this morning. The child is awake and crying.

Does this child have a general danger sign?

Possibly: "vomits everything" is a danger sign. Ask clearly whether the child vomits everything taken, and watch the child drink. If the child keeps nothing down, it is a danger sign.

If a danger sign is present, what changes?

The child is classified in a pink (severe) row. Finish the assessment quickly, give pre-referral treatment (for example first dose of an antimalarial or antibiotic per the fever chart, and treatment to prevent low blood sugar), and refer urgently.

Key points
  • Check every sick child for the general danger signs first.
  • Pink means urgent referral, yellow means specific treatment, green means home care.
  • Danger sign: do not delay; give pre-referral treatment and refer.
Lesson 2 of 6 · about 30 minutes

Cough or difficult breathing

By the end of this lesson you can
  • Count breaths, look for chest indrawing and classify cough or difficult breathing.
  • Treat pneumonia with oral amoxicillin and plan follow-up.

This lesson summarises the IMCI chart. The full one-page guide is the protocol Cough or difficult breathing in a child aged 2 months to 5 years.

Assess

  • Ask for how long the child has had cough or difficult breathing.
  • The child must be calm. Count the breaths in one full minute.
  • Look for chest indrawing; look and listen for stridor and wheeze.
  • If you have a pulse oximeter, refer if oxygen saturation is below 90%.
AgeFast breathing
2 months up to 12 months50 breaths per minute or more
12 months up to 5 years40 breaths per minute or more
SignsClassifyTreat
Any danger sign, or stridor in a calm childSevere pneumonia or very severe diseaseFirst dose of an appropriate antibiotic; refer urgently
Chest indrawing or fast breathingPneumoniaOral amoxicillin for 5 days; follow up in 3 days
NeitherCough or coldSoothe the throat with a safe remedy; follow up in 5 days if not improving
  • Amoxicillin: at least 40 mg/kg per dose twice daily. Dispersible 250 mg tablets: 1 tablet twice daily (2 to 12 months), 2 tablets (12 months to 3 years), 3 tablets (3 to 5 years).
  • Chest indrawing in a child who is HIV-exposed or infected: first dose of amoxicillin and refer.
  • Wheeze with fast breathing or chest indrawing: try a rapid-acting inhaled bronchodilator up to three times, 15 to 20 minutes apart, then reassess and classify.
  • Cough for more than 14 days or recurrent wheeze: refer for possible TB or asthma.
Case: Baby J, 9 months

Baby J, 9 months, has had a cough for 3 days. She is breastfeeding well and has no danger signs. Calm, her breathing rate is 54 per minute. There is no chest indrawing, stridor or wheeze. She weighs 8 kg. Her mother is HIV-negative.

How do you classify her?

Pneumonia: fast breathing (54 is above the 50 cut-off for 2 to 12 months), no danger signs and no stridor.

What treatment and follow-up?

Oral amoxicillin, dispersible 250 mg, 1 tablet twice daily for 5 days (3 days only if your national chart allows it for fast breathing alone in a low-HIV setting). Give the first dose in clinic, teach the mother, and follow up in 3 days; return at once if she cannot breastfeed, gets sicker or develops fever.

Key points
  • Count breaths for a full minute in a calm child; fast is 50 or more under 12 months, 40 or more from 12 months.
  • Chest indrawing or fast breathing without danger signs: oral amoxicillin at home, review in 3 days.
  • Danger sign or stridor: first dose of antibiotic and urgent referral.
Lesson 3 of 6 · about 35 minutes

Diarrhoea and dehydration

By the end of this lesson you can
  • Classify dehydration, persistent diarrhoea and dysentery.
  • Give fluid Plans A, B and C, zinc and feeding advice.

Assess

Ask for how long and whether there is blood in the stool. Look at the general condition (lethargic or unconscious? restless and irritable?), look for sunken eyes, offer the child a drink (not able to drink or drinking poorly? drinking eagerly?), and pinch the skin of the abdomen (goes back very slowly, more than 2 seconds? slowly?).

Two or more of these signsClassifyTreat
Lethargic or unconscious; sunken eyes; not able to drink or drinking poorly; skin pinch goes back very slowlySevere dehydrationPlan C (or refer urgently with ORS sips on the way if there is another severe classification)
Restless, irritable; sunken eyes; drinks eagerly, thirsty; skin pinch goes back slowlySome dehydrationPlan B, zinc, food; follow up in 5 days if not improving
Not enough signs for some or severeNo dehydrationPlan A, zinc, food; follow up in 5 days if not improving
  • Diarrhoea for 14 days or more: severe persistent diarrhoea if dehydrated (treat dehydration and refer), persistent diarrhoea if not (feeding advice, multivitamins and minerals including zinc for 14 days, follow up in 5 days).
  • Blood in the stool: dysentery. Give ciprofloxacin for 3 days (dose from your chart) and follow up in 3 days.
  • Child 2 years or older with severe dehydration where there is cholera: antibiotic for cholera.

Plan A: home treatment, four rules

  1. Give extra fluid: 50 to 100 mL of ORS after each loose stool under 2 years; 100 to 200 mL from 2 years. Breastfeed more often and for longer. Give 2 ORS packets to take home.
  2. Give zinc (20 mg tablet) for 14 days: half a tablet daily from 2 to 6 months; one tablet daily from 6 months.
  3. Continue feeding (exclusive breastfeeding under 6 months).
  4. Know when to return.

Plan B: some dehydration

Give about 75 mL/kg of ORS over 4 hours in the clinic, in small frequent sips from a cup. If the child vomits, wait 10 minutes and continue more slowly. After 4 hours, reassess, reclassify and choose the plan to continue.

Plan C: severe dehydration

If you can start IV fluid now, give Ringer's lactate (or normal saline) 100 mL/kg: 30 mL/kg in 1 hour then 70 mL/kg in 5 hours for infants under 12 months; 30 mL/kg in 30 minutes then 70 mL/kg in 2.5 hours from 12 months. If not, refer urgently if IV is available within 30 minutes; otherwise give ORS by nasogastric tube (or mouth) at 20 mL/kg per hour for 6 hours if you are trained.

Case: Child K, 18 months, 11 kg

K has had watery diarrhoea for 2 days, no blood. He is restless and irritable, his eyes are sunken, he drinks eagerly when offered water, and the skin pinch goes back slowly. No danger signs.

Classify and treat.

Some dehydration (at least two signs: restless and irritable, sunken eyes, drinks eagerly, slow skin pinch). Plan B: about 75 mL/kg, so about 800 mL of ORS over 4 hours in the clinic, then reassess.

After 4 hours he has no signs of dehydration. What does his mother take home?

Plan A: extra fluid (50 to 100 mL ORS after each loose stool), 2 ORS packets, zinc 20 mg one tablet daily for 14 days, continue feeding, and return at once if he drinks poorly, has blood in the stool, cannot drink or breastfeed, gets sicker or develops fever. Follow up in 5 days if not improving.

Key points
  • Classify dehydration on two or more signs: general condition, eyes, thirst, skin pinch.
  • Plan A at home, Plan B (75 mL/kg ORS over 4 hours) in clinic, Plan C for severe dehydration.
  • Zinc for 14 days for every child with diarrhoea from 2 months; ciprofloxacin for dysentery.
Lesson 4 of 6 · about 45 minutes

Fever: malaria, measles and very severe febrile disease

By the end of this lesson you can
  • Decide malaria risk, test, and classify fever.
  • Recognise measles and its complications and give vitamin A.
  • Treat malaria by test result, give pre-referral treatment for severe malaria, and follow up fever safely.

Fever means a history of fever, the child feels hot, or an axillary temperature of 37.5 °C or above. First decide the malaria risk: high, low, or none (and no travel to a malaria area).

Assess

  • Ask for how long; if more than 7 days, has the fever been present every day? Measles in the last 3 months?
  • Look or feel for a stiff neck; look for a runny nose; look for a bacterial cause (tender swelling, sores, painful limb, red tender skin, pain on passing urine in older children); look for signs of measles.
  • Do a malaria test: in every fever case in high-risk areas; in low-risk areas when there is no obvious cause.
Fever every day for more than 7 days: refer for assessment. Paracetamol for high fever as your chart shows.
Signs (malaria risk area)ClassifyTreat
Any danger sign or stiff neckVery severe febrile diseaseFirst dose of artesunate or quinine for severe malaria, first dose of antibiotic, prevent low blood sugar, refer urgently
Malaria test positiveMalariaFirst-line oral antimalarial per national policy; follow up in 3 days if fever persists
Test negative, or another cause foundFever: no malariaTreat the cause found; follow up in 3 days if fever persists

Malaria in practice

  • Test before you treat. Treat malaria only when the test is positive. If no test is available: in a high-risk area classify fever as malaria; in a low-risk area classify as malaria only if there is no obvious other cause.
  • No malaria risk and no travel to a malaria area: classify as fever, treat the cause found, and follow up in 2 days if fever persists.
  • First dose in the clinic. Give the first dose of the oral antimalarial (for example artemether-lumefantrine where it is first line) and watch the child for one hour; if the child vomits within an hour, repeat the dose. Give it with food.
  • Fever every day for more than 7 days: refer for assessment.
  • Severe malaria or very severe febrile disease: give the first dose of rectal or IM artesunate (or IM quinine) as your chart shows, the first dose of an antibiotic, prevent low blood sugar, and refer urgently. If referral is truly impossible, continue the pre-referral treatment as the chart and national policy describe.

The one-page guides are Fever in a child under 5, Uncomplicated malaria and Severe malaria: pre-referral treatment. Use the antimalarial and doses in your national policy.

Malaria not getting betterAt the 3-day follow-up for malaria: if any danger sign or stiff neck, treat as very severe febrile disease. If fever persists without other cause, do not repeat the rapid test (it can stay positive after treatment); use microscopy if available, or give second-line treatment or refer, as your chart says.

Measles

Measles is a generalised rash with one of cough, runny nose or red eyes. In a child with measles now or in the last 3 months, look for mouth ulcers (deep and extensive?), pus draining from the eye and clouding of the cornea.

SignsClassifyTreat
Any danger sign, clouding of the cornea, or deep or extensive mouth ulcersSevere complicated measlesVitamin A, first dose of antibiotic, tetracycline eye ointment if eye signs, refer urgently
Pus draining from the eye, or mouth ulcersMeasles with eye or mouth complicationsVitamin A, tetracycline eye ointment, gentian violet for ulcers, follow up in 3 days
Measles now or in the last 3 monthsMeaslesVitamin A

Pneumonia, stridor, diarrhoea, ear infection and malnutrition after measles are classified in their own charts.

Second case: fever in a low-risk area

Child N, 4 years, lives in a low malaria risk area. He has had fever for 3 days and has a hot, tender swelling on his left thigh that he will not let you touch. No danger signs, no stiff neck, no rash, no cough. He has not travelled.

Second case: model answers1. Should you do a malaria test?
In a low-risk area, test only if there is no obvious cause of fever. A hot, tender swelling is a sign of a bacterial cause, so a test is not required; test if you are unsure the swelling explains the fever.
2. What if the test is negative?
Classify as fever: no malaria. Treat the bacterial cause as your chart and protocol show (a deep collection may need referral), give paracetamol for high fever, advise when to return immediately, and follow up in 3 days if fever persists. Refer if the fever has been present every day for more than 7 days.
Case: Child L, 3 years, high malaria risk area

L has had fever for 2 days. No danger signs, no stiff neck, no rash, no cough. The malaria rapid test is positive. She is eating and drinking.

How do you classify and treat?

Malaria (yellow). Give the recommended first-line oral antimalarial for your country, paracetamol for high fever, advise when to return immediately, and follow up in 3 days if the fever persists.

Two days later she cannot drink and is very sleepy. What now?

Lethargy and inability to drink are danger signs: very severe febrile disease. Give the first dose of artesunate or quinine for severe malaria, a first dose of antibiotic, prevent low blood sugar and refer urgently.

Key points
  • Decide malaria risk; test for malaria before giving antimalarials.
  • Treat malaria by test result; observe the first dose for an hour and repeat it if vomited; refer fever present every day for more than 7 days.
  • Danger sign or stiff neck with fever: very severe febrile disease; pre-referral antimalarial and antibiotic, refer.
  • Every child with measles gets vitamin A; refer if the cornea is clouded or mouth ulcers are deep.
Lesson 5 of 6 · about 45 minutes

Malnutrition, anaemia, feeding counselling and follow-up

By the end of this lesson you can
  • Classify acute malnutrition with MUAC, weight-for-height and oedema, and classify anaemia by palmar pallor.
  • Counsel the carer on fluids, feeding and when to return, and plan follow-up.
  • Assess a child's feeding and give age-appropriate feeding advice.

Acute malnutrition

Look for oedema of both feet, find the weight-for-height or length z-score, and measure MUAC in children 6 months or older.

SignsClassifyAction
Oedema of both feet, or WFH/L below -3 z or MUAC under 115 mm with a medical complication, unable to finish RUTF, or a breastfeeding problemComplicated severe acute malnutritionFirst dose of antibiotic, prevent low blood sugar, keep warm, refer urgently
WFH/L below -3 z or MUAC under 115 mm, finishes RUTFUncomplicated severe acute malnutritionOral antibiotics 5 days, RUTF, feeding counselling, assess for TB, follow up in 7 days
WFH/L -3 to -2 z, or MUAC 115 to under 125 mmModerate acute malnutritionAssess feeding and counsel; assess for TB; follow up in 30 days
WFH/L -2 z or more, or MUAC 125 mm or moreNo acute malnutritionUnder 2 years: assess feeding and counsel

Anaemia

  • Severe palmar pallor: severe anaemia, refer urgently.
  • Some palmar pallor: anaemia. Give iron (not if the child is on RUTF, which already contains iron); mebendazole if 1 year or older and none in the last 6 months; follow up in 14 days. Keep giving iron daily, with a review and a new supply every 14 days, for 2 months, and refer if still pale after 2 months.
  • Assess for sickle cell disease where it is common.

Assess feeding

Assess feeding in every child under 2 years, and in any child with moderate acute malnutrition, anaemia, or confirmed or exposed HIV. Ask how the child is fed and compare the answers with the recommendations for the child's age.

  • Breastfeeding: how many times a day? At night too?
  • Other foods or fluids: what, how many times a day, and with what (cup, bottle, spoon)?
  • For a child with moderate acute malnutrition or poor growth: how large are servings? Does the child have their own plate? Who feeds the child, and how? What food is available at home?
  • During this illness, has feeding changed?

IMCI feeding recommendations

Adapted from the WHO IMCI chart booklet (2014), counselling section. A good daily diet includes an energy-rich food (such as thick cereal with added oil), meat, fish, eggs or pulses, and fruit and vegetables.
AgeRecommendation
Birth up to 6 monthsBreastfeed only, as often as the child wants, day and night, at least 8 times in 24 hours. No other food or water
6 up to 9 monthsBreastfeed as often as the child wants. Add thick porridge or well-mashed foods, including animal-source foods and vitamin A-rich fruit and vegetables. Start with 2 to 3 tablespoons and build up to half a cup (250 mL cup). 2 to 3 meals a day plus 1 to 2 snacks
9 up to 12 monthsBreastfeed as often as the child wants. Mashed or finely chopped family food. Half a cup at each meal, 3 to 4 meals a day, plus 1 to 2 snacks
12 months up to 2 yearsBreastfeed as often as the child wants. Family food; three-quarters of a cup at each meal, 3 to 4 meals a day, plus 1 to 2 snacks. Feed slowly and patiently; encourage but do not force
2 years and olderA variety of family foods, including animal-source foods and vitamin A-rich fruit and vegetables. At least 1 full cup at each meal, 3 to 4 meals a day, plus 1 to 2 snacks

Name one or two specific changes, not a list of everything. Praise what the carer is doing well. If you find a feeding problem, arrange follow-up in 5 to 7 days, as the chart row for that child says. Children with severe acute malnutrition need the Acute malnutrition in children protocol; in emergencies see Malnutrition in emergencies.

Counsel the carer

  • Fluids: breastfeed more often and for longer; increase other fluids such as soup, rice water or clean water.
  • Feeding: keep feeding during and after illness, following the feeding recommendations for the child's age.
  • Show how to give oral medicines at home and check the carer can do it before leaving.
  • Look after the mother's own health too: tetanus vaccine, family planning, her own illness.
Return immediately ifAny sick child: not able to drink or breastfeed, becomes sicker, or develops a fever. Cough or cold: also fast or difficult breathing. Diarrhoea: also blood in the stool or drinking poorly.
If a child has more than one problem, come back at the earliest time.
ClassificationFollow-up
Pneumonia, dysentery, malaria or fever if fever persists, measles with eye or mouth complications3 days
Persistent diarrhoea, ear infection, cough or cold or diarrhoea if not improving5 days
Uncomplicated severe acute malnutrition, feeding problem7 days
Anaemia14 days
Moderate acute malnutrition30 days

Second case: a feeding problem at 10 months

Baby P, 10 months, comes for a cough. She has no danger signs and is classified as cough or cold. MUAC is 128 mm, no oedema, no pallor. Her mother breastfeeds 4 times a day and gives thin porridge twice a day from a bottle. She has never given egg, fish or meat because she thought the baby was too young.

Second case: model answers1. What is her nutritional classification, and is there a feeding problem?
No acute malnutrition (MUAC 125 mm or more, no oedema). There is a feeding problem: breastfeeding less often than recommended, too few meals, thin porridge, no animal-source foods, and bottle use.
2. What do you advise?
Breastfeed as often as she wants, day and night; give mashed or finely chopped family food, half a cup 3 to 4 times a day plus 1 to 2 snacks, including egg, fish, meat or pulses and vitamin A-rich fruit and vegetables; use a cup instead of a bottle. Choose the two changes the mother feels able to make first, and follow up the feeding problem as your chart says.
Case: Child M, 14 months

M comes with diarrhoea for 3 days and no dehydration. He has no oedema; MUAC is 119 mm. His palms show some pallor. He has never had mebendazole.

What are his classifications?

Diarrhoea with no dehydration; moderate acute malnutrition (MUAC 115 to under 125 mm); anaemia (some palmar pallor).

What do you give, and when do you see him again?

Plan A with zinc for 14 days; iron (he is not on RUTF); mebendazole (over 1 year, none in 6 months); feeding assessment and counselling; assess for TB. Return at the earliest follow-up: 5 days if the diarrhoea is not improving, otherwise 14 days for anaemia, and 30 days for MUAC. Explain when to return immediately.

Key points
  • MUAC under 115 mm or oedema of both feet is severe acute malnutrition; refer if complicated.
  • Some palmar pallor: iron (not with RUTF) and mebendazole from 1 year; severe pallor: refer.
  • Assess feeding in every child under 2 and in malnutrition, anaemia or HIV; compare with the age recommendations and agree one or two changes.
  • Every carer leaves knowing when to return immediately and when to come for follow-up.
Lesson 6 of 6 · about 60 minutes

The sick young infant and the HIV-exposed infant

By the end of this lesson you can
  • Assess and classify a sick young infant (birth up to 2 months) with the WHO 7-sign algorithm for possible serious bacterial infection.
  • Give pre-referral treatment, and know the WHO options when referral is not possible.
  • Give an HIV-exposed infant prophylaxis, testing and follow-up until a final diagnosis.

About 3 million young infants die every year in the first 59 days of life, 98% of them in low- and middle-income countries, and sepsis, meningitis and pneumonia cause more than half a million of these deaths. Signs are often subtle and change fast: a baby who feeds poorly or moves less may be very ill. Young infants up to 2 months (0 to 59 days) are assessed with their own chart.

Possible serious bacterial infection: the 7 signs

  • Not feeding well, or not able to feed at all.
  • Convulsions.
  • Fast breathing, 60 breaths per minute or more, in an infant aged 0 to 6 days (count for a full minute in a calm infant; repeat if high).
  • Severe chest indrawing.
  • Temperature 38 °C or above.
  • Temperature below 35.5 °C.
  • Movement only when stimulated, or no movement at all.

Source: WHO recommendations for management of serious bacterial infections in infants aged 0 to 59 days, 2024

Adapted from WHO (2024) serious bacterial infection recommendations and the IMCI chart booklet (2014). Doses: see the protocol and your national chart.
SignsClassifyAction
Not able to feed at all, no movement at all, or convulsionsCritical illnessPre-referral treatment; refer urgently. If referral is not possible: injectable ampicillin plus gentamicin for at least 10 days
Not feeding well, movement only when stimulated, temperature 38 °C or above or below 35.5 °C, or severe chest indrawingClinical severe infectionPre-referral treatment; refer. If referral is not possible: oral amoxicillin for at least 7 days plus gentamicin for at least 7 days (or 2 days if 7 is not feasible)
Fast breathing as the only sign, age 0 to 6 daysFast breathing in the first weekRefer. If referral is not possible: oral amoxicillin for at least 7 days
Fast breathing as the only sign, age 7 to 59 daysFast breathing (pneumonia)Oral amoxicillin for at least 7 days at home; close follow-up
Red or pus-draining umbilicus, or skin pustulesLocal bacterial infectionOral antibiotic; teach home treatment; follow up in 2 days
None of theseSevere disease or local infection unlikelyHome care advice

Before referral: give the first IM dose of ampicillin and gentamicin, prevent low blood sugar (breastfeed, or give expressed breast milk or sugar water by cup or tube) and keep the infant warm on the way, ideally skin to skin with the mother. When the family cannot reach or accept referral, the outpatient regimens above need daily visits and a careful check on day 4. The one-page guide with doses is The sick young infant up to 2 months.

Also check every young infant for

ProblemSevere (pink)Action
JaundiceAny jaundice under 24 hours of age, or yellow palms and soles at any agePrevent low blood sugar, keep warm, refer urgently. Jaundice after 24 hours with normal palms and soles: home care, review in 1 day, refer if the infant is older than 14 days
DiarrhoeaTwo of: moves only when stimulated or not at all, sunken eyes, skin pinch goes back very slowlyPlan C, or refer urgently with sips of ORS if there is another severe classification; keep breastfeeding
Feeding problem or low weightNot able to feed (this is critical illness)Not well attached, not suckling well, fewer than 8 breastfeeds in 24 hours, other foods or drinks, thrush or low weight: teach positioning and attachment, more frequent breastfeeds, follow up in 2 days (low weight in 14 days)

The HIV-exposed infant

Ask about the mother's HIV status at every young infant visit. If she has never been tested, test her; if she is positive, the infant needs a virological test. Antibody tests cannot diagnose HIV in a child under 18 months, because the mother's antibodies can persist until then.

WHO Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring (2021); IMCI chart booklet (2014). Use the regimens and doses in your national programme.
StepWhat WHO recommends
MotherLifelong ART for every pregnant or breastfeeding woman with HIV, started urgently; this is the most effective way to prevent transmission
Infant prophylaxisBreastfed infant of a mother on ART: daily nevirapine for 6 weeks (4 to 6 weeks if replacement fed). High-risk infant (mother on ART less than 4 weeks at delivery, viral load above 1000 copies/mL, new infection in pregnancy or breastfeeding, or first diagnosed after birth): dual prophylaxis with zidovudine and nevirapine for 6 weeks, and a further 6 weeks if breastfed
TestingNucleic acid (virological) test at 4 to 6 weeks of age; some programmes add a test at birth. Point-of-care tests are recommended where available
Co-trimoxazoleFrom 4 to 6 weeks of age, until HIV is excluded by an age-appropriate test after breastfeeding has completely stopped
FeedingMothers with HIV should breastfeed for at least 12 months, and may continue up to 24 months or longer, with full support for ART adherence. Exclusive breastfeeding for the first 6 months
Final diagnosisAt 18 months of age, or 3 months after breastfeeding ends, whichever is later. Keep the child in follow-up until then

An infant with a positive virological test needs ART and HIV care started without delay, with co-trimoxazole: see HIV testing and starting ART. In the IMCI sick child chart, an HIV-exposed or HIV-infected child with chest indrawing is referred, and every HIV-exposed child has feeding assessed (lesson 5).

Do not lose the infantEvery HIV-exposed infant leaves with: the date of the next visit, the date of the virological test, co-trimoxazole from 4 to 6 weeks, and the mother's next ART appointment. Missed visits are found and followed up.

Second case: an HIV-exposed infant at 6 weeks

Baby R, 6 weeks, comes for immunisation. His mother has been on ART since early pregnancy and her last viral load was suppressed. He is exclusively breastfed and has taken nevirapine since birth. He is well, feeding well, and his weight is normal for age. He has not had an HIV test.

Second case: model answers1. What does he need today?
A virological (nucleic acid) test, start co-trimoxazole prophylaxis, his immunisations, and completion of his 6 weeks of nevirapine. Assess feeding and praise exclusive breastfeeding.
2. How long does follow-up continue?
Until a final diagnosis: at 18 months, or 3 months after breastfeeding ends, whichever is later. Co-trimoxazole continues until HIV is excluded after breastfeeding has stopped completely.
Case: Baby Q, 12 days, 'not feeding well'

Baby Q, 12 days old, is brought because she has fed poorly since yesterday. She is calm; her breathing rate is 64 per minute on two counts. There is no severe chest indrawing. Her axillary temperature is 38.4 °C. She moves only when stimulated. The umbilicus is clean. Her mother is HIV-negative.

How do you classify her?

Possible serious bacterial infection: she has several of the 7 signs (not feeding well, temperature 38 °C or above, movement only when stimulated). She can still feed and moves when stimulated, so she has clinical severe infection rather than critical illness. At 12 days, fast breathing on its own would be treated with oral amoxicillin, but here it comes with other signs, so the severe classification applies.

What do you do before she leaves the clinic?

Give the first IM doses of ampicillin and gentamicin, prevent low blood sugar (breastfeed or expressed milk by cup), keep her warm skin to skin, and refer urgently with a note.

The family cannot go to hospital. What then?

Explain the risks and keep encouraging referral. If referral is truly not possible, WHO recommends oral amoxicillin for at least 7 days plus gentamicin for at least 7 days (or for 2 days if 7 days of injections is not feasible), with daily contact and a careful check on day 4. Refer at once if she develops a sign of critical illness or is not improving.

Key points
  • The 7 signs: not feeding well, convulsions, fast breathing at 0 to 6 days, severe chest indrawing, 38 °C or above, below 35.5 °C, movement only when stimulated or none.
  • Critical illness or clinical severe infection: first-dose antibiotics, prevent low sugar, keep warm, refer. Outpatient regimens only when referral is impossible.
  • Fast breathing alone at 7 to 59 days: oral amoxicillin for at least 7 days at home.
  • HIV-exposed infant: infant prophylaxis, virological test at 4 to 6 weeks, co-trimoxazole from 4 to 6 weeks, breastfeeding with maternal ART, follow-up to a final diagnosis.
Final quiz

Quiz and CPD certificate

Answer all 15 questions, then press Mark. You need 12 or more to pass. You can look back at the lessons: the aim is learning. A pass gives a printable certificate of completion for 4 hours of self-directed learning; you need a free account, signed in, to issue it.

Sources

  1. World Health Organization. Integrated Management of Childhood Illness (IMCI) chart booklet. 2014 (ISBN 9789241506823).
  2. World Health Organization. Revised WHO classification and treatment of pneumonia in children at health facilities: evidence summaries. 2014.
  3. World Health Organization. Guideline on management of pneumonia and diarrhoea in children up to 10 years of age. 2024.
  4. World Health Organization. WHO recommendations for management of serious bacterial infections in infants aged 0 to 59 days. 2024 (ISBN 9789240102903).
  5. World Health Organization. Guideline: managing possible serious bacterial infection in young infants when referral is not feasible. 2015 (ISBN 9789241509268).
  6. World Health Organization. Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. 2021 (ISBN 9789240031593).
  7. World Health Organization. WHO guideline on the prevention and management of wasting and nutritional oedema (acute malnutrition) in infants and children under 5 years. 2023.
Adapted from WHO guidance; not endorsed by WHO. This page paraphrases and adapts the WHO publications listed under Sources, which are licensed CC BY-NC-SA 3.0 IGO; the adapted text is shared under the same licence for non-commercial education. Reasoning GP is not affiliated with WHO or any other organisation named here. Use it alongside your national guidelines, essential medicines list and formulary, and your clinical judgement. Doses are given only where they come from a WHO source; otherwise follow your national guideline or formulary.