The sick child: IMCI in practice
Integrated Management of Childhood Illness (IMCI) gives first-level health workers one simple routine for every sick child: check for danger signs, ask about the main symptoms, classify by colour, treat, counsel and follow up. This course works through the WHO IMCI chart booklet (2014) for children aged 2 months up to 5 years and for young infants up to 2 months, updated with the WHO 2024 recommendations on serious bacterial infection in young infants and the WHO HIV guidelines, with cases from a busy clinic.
- Check every sick child for general danger signs and act on them.
- Assess and classify cough, diarrhoea and fever using the IMCI colour-coded chart, and link fever to malaria testing and treatment.
- Give the right home treatment: amoxicillin, ORS and zinc, antimalarials, vitamin A, iron.
- Check for acute malnutrition and anaemia, assess feeding and counsel the carer using the IMCI feeding recommendations, and plan follow-up.
- Assess and classify the sick young infant up to 2 months, and give the HIV-exposed infant prophylaxis, testing and follow-up.
The IMCI approach and general danger signs
- Describe the IMCI case-management process and its colour coding.
- Check for the general danger signs and know what to do when one is present.
Most children who die before their fifth birthday die of a few common illnesses, often more than one at a time: pneumonia, diarrhoea, malaria, measles and malnutrition. IMCI was designed so that a health worker with a chart can find all of a child's problems at one visit, rather than treating only the one the carer mentions.
The routine
- Ask what the child's problems are. Is this a first visit or a follow-up for this problem?
- Check for general danger signs.
- Ask about the main symptoms: cough or difficult breathing, diarrhoea, fever, ear problem.
- Check for acute malnutrition and anaemia, HIV status, immunisation and feeding.
- Classify each problem, identify treatment, treat, counsel the carer and plan follow-up.
| Colour | Means | Typical action |
|---|---|---|
| Pink | Severe classification | Pre-referral treatment and urgent referral |
| Yellow | Needs specific treatment | Treat at the clinic or at home, follow up |
| Green | Home care | Advice on home care and when to return |
General danger signs
- Not able to drink or breastfeed.
- Vomits everything.
- Has had convulsions in this illness.
- Lethargic or unconscious.
- Convulsing now.
Preventing low blood sugar
If the child can breastfeed, ask the mother to breastfeed. If not, but the child can swallow, give expressed breast milk or a breast-milk substitute, or sugar water (4 level teaspoons of sugar in a 200 mL cup of clean water): 30 to 50 mL before departure. If the child cannot swallow and you are trained, give 50 mL by nasogastric tube.
A mother brings her 2-year-old with fever for 2 days. While you wait, she tells you the child vomited after every drink this morning. The child is awake and crying.
Does this child have a general danger sign?
Possibly: "vomits everything" is a danger sign. Ask clearly whether the child vomits everything taken, and watch the child drink. If the child keeps nothing down, it is a danger sign.
If a danger sign is present, what changes?
The child is classified in a pink (severe) row. Finish the assessment quickly, give pre-referral treatment (for example first dose of an antimalarial or antibiotic per the fever chart, and treatment to prevent low blood sugar), and refer urgently.
- Check every sick child for the general danger signs first.
- Pink means urgent referral, yellow means specific treatment, green means home care.
- Danger sign: do not delay; give pre-referral treatment and refer.
Cough or difficult breathing
- Count breaths, look for chest indrawing and classify cough or difficult breathing.
- Treat pneumonia with oral amoxicillin and plan follow-up.
This lesson summarises the IMCI chart. The full one-page guide is the protocol Cough or difficult breathing in a child aged 2 months to 5 years.
Assess
- Ask for how long the child has had cough or difficult breathing.
- The child must be calm. Count the breaths in one full minute.
- Look for chest indrawing; look and listen for stridor and wheeze.
- If you have a pulse oximeter, refer if oxygen saturation is below 90%.
| Age | Fast breathing |
|---|---|
| 2 months up to 12 months | 50 breaths per minute or more |
| 12 months up to 5 years | 40 breaths per minute or more |
| Signs | Classify | Treat |
|---|---|---|
| Any danger sign, or stridor in a calm child | Severe pneumonia or very severe disease | First dose of an appropriate antibiotic; refer urgently |
| Chest indrawing or fast breathing | Pneumonia | Oral amoxicillin for 5 days; follow up in 3 days |
| Neither | Cough or cold | Soothe the throat with a safe remedy; follow up in 5 days if not improving |
- Amoxicillin: at least 40 mg/kg per dose twice daily. Dispersible 250 mg tablets: 1 tablet twice daily (2 to 12 months), 2 tablets (12 months to 3 years), 3 tablets (3 to 5 years).
- Chest indrawing in a child who is HIV-exposed or infected: first dose of amoxicillin and refer.
- Wheeze with fast breathing or chest indrawing: try a rapid-acting inhaled bronchodilator up to three times, 15 to 20 minutes apart, then reassess and classify.
- Cough for more than 14 days or recurrent wheeze: refer for possible TB or asthma.
Baby J, 9 months, has had a cough for 3 days. She is breastfeeding well and has no danger signs. Calm, her breathing rate is 54 per minute. There is no chest indrawing, stridor or wheeze. She weighs 8 kg. Her mother is HIV-negative.
How do you classify her?
Pneumonia: fast breathing (54 is above the 50 cut-off for 2 to 12 months), no danger signs and no stridor.
What treatment and follow-up?
Oral amoxicillin, dispersible 250 mg, 1 tablet twice daily for 5 days (3 days only if your national chart allows it for fast breathing alone in a low-HIV setting). Give the first dose in clinic, teach the mother, and follow up in 3 days; return at once if she cannot breastfeed, gets sicker or develops fever.
- Count breaths for a full minute in a calm child; fast is 50 or more under 12 months, 40 or more from 12 months.
- Chest indrawing or fast breathing without danger signs: oral amoxicillin at home, review in 3 days.
- Danger sign or stridor: first dose of antibiotic and urgent referral.
Diarrhoea and dehydration
- Classify dehydration, persistent diarrhoea and dysentery.
- Give fluid Plans A, B and C, zinc and feeding advice.
Assess
Ask for how long and whether there is blood in the stool. Look at the general condition (lethargic or unconscious? restless and irritable?), look for sunken eyes, offer the child a drink (not able to drink or drinking poorly? drinking eagerly?), and pinch the skin of the abdomen (goes back very slowly, more than 2 seconds? slowly?).
| Two or more of these signs | Classify | Treat |
|---|---|---|
| Lethargic or unconscious; sunken eyes; not able to drink or drinking poorly; skin pinch goes back very slowly | Severe dehydration | Plan C (or refer urgently with ORS sips on the way if there is another severe classification) |
| Restless, irritable; sunken eyes; drinks eagerly, thirsty; skin pinch goes back slowly | Some dehydration | Plan B, zinc, food; follow up in 5 days if not improving |
| Not enough signs for some or severe | No dehydration | Plan A, zinc, food; follow up in 5 days if not improving |
- Diarrhoea for 14 days or more: severe persistent diarrhoea if dehydrated (treat dehydration and refer), persistent diarrhoea if not (feeding advice, multivitamins and minerals including zinc for 14 days, follow up in 5 days).
- Blood in the stool: dysentery. Give ciprofloxacin for 3 days (dose from your chart) and follow up in 3 days.
- Child 2 years or older with severe dehydration where there is cholera: antibiotic for cholera.
Plan A: home treatment, four rules
- Give extra fluid: 50 to 100 mL of ORS after each loose stool under 2 years; 100 to 200 mL from 2 years. Breastfeed more often and for longer. Give 2 ORS packets to take home.
- Give zinc (20 mg tablet) for 14 days: half a tablet daily from 2 to 6 months; one tablet daily from 6 months.
- Continue feeding (exclusive breastfeeding under 6 months).
- Know when to return.
Plan B: some dehydration
Give about 75 mL/kg of ORS over 4 hours in the clinic, in small frequent sips from a cup. If the child vomits, wait 10 minutes and continue more slowly. After 4 hours, reassess, reclassify and choose the plan to continue.
Plan C: severe dehydration
If you can start IV fluid now, give Ringer's lactate (or normal saline) 100 mL/kg: 30 mL/kg in 1 hour then 70 mL/kg in 5 hours for infants under 12 months; 30 mL/kg in 30 minutes then 70 mL/kg in 2.5 hours from 12 months. If not, refer urgently if IV is available within 30 minutes; otherwise give ORS by nasogastric tube (or mouth) at 20 mL/kg per hour for 6 hours if you are trained.
K has had watery diarrhoea for 2 days, no blood. He is restless and irritable, his eyes are sunken, he drinks eagerly when offered water, and the skin pinch goes back slowly. No danger signs.
Classify and treat.
Some dehydration (at least two signs: restless and irritable, sunken eyes, drinks eagerly, slow skin pinch). Plan B: about 75 mL/kg, so about 800 mL of ORS over 4 hours in the clinic, then reassess.
After 4 hours he has no signs of dehydration. What does his mother take home?
Plan A: extra fluid (50 to 100 mL ORS after each loose stool), 2 ORS packets, zinc 20 mg one tablet daily for 14 days, continue feeding, and return at once if he drinks poorly, has blood in the stool, cannot drink or breastfeed, gets sicker or develops fever. Follow up in 5 days if not improving.
- Classify dehydration on two or more signs: general condition, eyes, thirst, skin pinch.
- Plan A at home, Plan B (75 mL/kg ORS over 4 hours) in clinic, Plan C for severe dehydration.
- Zinc for 14 days for every child with diarrhoea from 2 months; ciprofloxacin for dysentery.
Fever: malaria, measles and very severe febrile disease
- Decide malaria risk, test, and classify fever.
- Recognise measles and its complications and give vitamin A.
- Treat malaria by test result, give pre-referral treatment for severe malaria, and follow up fever safely.
Fever means a history of fever, the child feels hot, or an axillary temperature of 37.5 °C or above. First decide the malaria risk: high, low, or none (and no travel to a malaria area).
Assess
- Ask for how long; if more than 7 days, has the fever been present every day? Measles in the last 3 months?
- Look or feel for a stiff neck; look for a runny nose; look for a bacterial cause (tender swelling, sores, painful limb, red tender skin, pain on passing urine in older children); look for signs of measles.
- Do a malaria test: in every fever case in high-risk areas; in low-risk areas when there is no obvious cause.
| Signs (malaria risk area) | Classify | Treat |
|---|---|---|
| Any danger sign or stiff neck | Very severe febrile disease | First dose of artesunate or quinine for severe malaria, first dose of antibiotic, prevent low blood sugar, refer urgently |
| Malaria test positive | Malaria | First-line oral antimalarial per national policy; follow up in 3 days if fever persists |
| Test negative, or another cause found | Fever: no malaria | Treat the cause found; follow up in 3 days if fever persists |
Malaria in practice
- Test before you treat. Treat malaria only when the test is positive. If no test is available: in a high-risk area classify fever as malaria; in a low-risk area classify as malaria only if there is no obvious other cause.
- No malaria risk and no travel to a malaria area: classify as fever, treat the cause found, and follow up in 2 days if fever persists.
- First dose in the clinic. Give the first dose of the oral antimalarial (for example artemether-lumefantrine where it is first line) and watch the child for one hour; if the child vomits within an hour, repeat the dose. Give it with food.
- Fever every day for more than 7 days: refer for assessment.
- Severe malaria or very severe febrile disease: give the first dose of rectal or IM artesunate (or IM quinine) as your chart shows, the first dose of an antibiotic, prevent low blood sugar, and refer urgently. If referral is truly impossible, continue the pre-referral treatment as the chart and national policy describe.
The one-page guides are Fever in a child under 5, Uncomplicated malaria and Severe malaria: pre-referral treatment. Use the antimalarial and doses in your national policy.
Measles
Measles is a generalised rash with one of cough, runny nose or red eyes. In a child with measles now or in the last 3 months, look for mouth ulcers (deep and extensive?), pus draining from the eye and clouding of the cornea.
| Signs | Classify | Treat |
|---|---|---|
| Any danger sign, clouding of the cornea, or deep or extensive mouth ulcers | Severe complicated measles | Vitamin A, first dose of antibiotic, tetracycline eye ointment if eye signs, refer urgently |
| Pus draining from the eye, or mouth ulcers | Measles with eye or mouth complications | Vitamin A, tetracycline eye ointment, gentian violet for ulcers, follow up in 3 days |
| Measles now or in the last 3 months | Measles | Vitamin A |
Pneumonia, stridor, diarrhoea, ear infection and malnutrition after measles are classified in their own charts.
Second case: fever in a low-risk area
Child N, 4 years, lives in a low malaria risk area. He has had fever for 3 days and has a hot, tender swelling on his left thigh that he will not let you touch. No danger signs, no stiff neck, no rash, no cough. He has not travelled.
In a low-risk area, test only if there is no obvious cause of fever. A hot, tender swelling is a sign of a bacterial cause, so a test is not required; test if you are unsure the swelling explains the fever.
2. What if the test is negative?
Classify as fever: no malaria. Treat the bacterial cause as your chart and protocol show (a deep collection may need referral), give paracetamol for high fever, advise when to return immediately, and follow up in 3 days if fever persists. Refer if the fever has been present every day for more than 7 days.
L has had fever for 2 days. No danger signs, no stiff neck, no rash, no cough. The malaria rapid test is positive. She is eating and drinking.
How do you classify and treat?
Malaria (yellow). Give the recommended first-line oral antimalarial for your country, paracetamol for high fever, advise when to return immediately, and follow up in 3 days if the fever persists.
Two days later she cannot drink and is very sleepy. What now?
Lethargy and inability to drink are danger signs: very severe febrile disease. Give the first dose of artesunate or quinine for severe malaria, a first dose of antibiotic, prevent low blood sugar and refer urgently.
- Decide malaria risk; test for malaria before giving antimalarials.
- Treat malaria by test result; observe the first dose for an hour and repeat it if vomited; refer fever present every day for more than 7 days.
- Danger sign or stiff neck with fever: very severe febrile disease; pre-referral antimalarial and antibiotic, refer.
- Every child with measles gets vitamin A; refer if the cornea is clouded or mouth ulcers are deep.
Malnutrition, anaemia, feeding counselling and follow-up
- Classify acute malnutrition with MUAC, weight-for-height and oedema, and classify anaemia by palmar pallor.
- Counsel the carer on fluids, feeding and when to return, and plan follow-up.
- Assess a child's feeding and give age-appropriate feeding advice.
Acute malnutrition
Look for oedema of both feet, find the weight-for-height or length z-score, and measure MUAC in children 6 months or older.
| Signs | Classify | Action |
|---|---|---|
| Oedema of both feet, or WFH/L below -3 z or MUAC under 115 mm with a medical complication, unable to finish RUTF, or a breastfeeding problem | Complicated severe acute malnutrition | First dose of antibiotic, prevent low blood sugar, keep warm, refer urgently |
| WFH/L below -3 z or MUAC under 115 mm, finishes RUTF | Uncomplicated severe acute malnutrition | Oral antibiotics 5 days, RUTF, feeding counselling, assess for TB, follow up in 7 days |
| WFH/L -3 to -2 z, or MUAC 115 to under 125 mm | Moderate acute malnutrition | Assess feeding and counsel; assess for TB; follow up in 30 days |
| WFH/L -2 z or more, or MUAC 125 mm or more | No acute malnutrition | Under 2 years: assess feeding and counsel |
Anaemia
- Severe palmar pallor: severe anaemia, refer urgently.
- Some palmar pallor: anaemia. Give iron (not if the child is on RUTF, which already contains iron); mebendazole if 1 year or older and none in the last 6 months; follow up in 14 days. Keep giving iron daily, with a review and a new supply every 14 days, for 2 months, and refer if still pale after 2 months.
- Assess for sickle cell disease where it is common.
Assess feeding
Assess feeding in every child under 2 years, and in any child with moderate acute malnutrition, anaemia, or confirmed or exposed HIV. Ask how the child is fed and compare the answers with the recommendations for the child's age.
- Breastfeeding: how many times a day? At night too?
- Other foods or fluids: what, how many times a day, and with what (cup, bottle, spoon)?
- For a child with moderate acute malnutrition or poor growth: how large are servings? Does the child have their own plate? Who feeds the child, and how? What food is available at home?
- During this illness, has feeding changed?
IMCI feeding recommendations
| Age | Recommendation |
|---|---|
| Birth up to 6 months | Breastfeed only, as often as the child wants, day and night, at least 8 times in 24 hours. No other food or water |
| 6 up to 9 months | Breastfeed as often as the child wants. Add thick porridge or well-mashed foods, including animal-source foods and vitamin A-rich fruit and vegetables. Start with 2 to 3 tablespoons and build up to half a cup (250 mL cup). 2 to 3 meals a day plus 1 to 2 snacks |
| 9 up to 12 months | Breastfeed as often as the child wants. Mashed or finely chopped family food. Half a cup at each meal, 3 to 4 meals a day, plus 1 to 2 snacks |
| 12 months up to 2 years | Breastfeed as often as the child wants. Family food; three-quarters of a cup at each meal, 3 to 4 meals a day, plus 1 to 2 snacks. Feed slowly and patiently; encourage but do not force |
| 2 years and older | A variety of family foods, including animal-source foods and vitamin A-rich fruit and vegetables. At least 1 full cup at each meal, 3 to 4 meals a day, plus 1 to 2 snacks |
Name one or two specific changes, not a list of everything. Praise what the carer is doing well. If you find a feeding problem, arrange follow-up in 5 to 7 days, as the chart row for that child says. Children with severe acute malnutrition need the Acute malnutrition in children protocol; in emergencies see Malnutrition in emergencies.
Counsel the carer
- Fluids: breastfeed more often and for longer; increase other fluids such as soup, rice water or clean water.
- Feeding: keep feeding during and after illness, following the feeding recommendations for the child's age.
- Show how to give oral medicines at home and check the carer can do it before leaving.
- Look after the mother's own health too: tetanus vaccine, family planning, her own illness.
| Classification | Follow-up |
|---|---|
| Pneumonia, dysentery, malaria or fever if fever persists, measles with eye or mouth complications | 3 days |
| Persistent diarrhoea, ear infection, cough or cold or diarrhoea if not improving | 5 days |
| Uncomplicated severe acute malnutrition, feeding problem | 7 days |
| Anaemia | 14 days |
| Moderate acute malnutrition | 30 days |
Second case: a feeding problem at 10 months
Baby P, 10 months, comes for a cough. She has no danger signs and is classified as cough or cold. MUAC is 128 mm, no oedema, no pallor. Her mother breastfeeds 4 times a day and gives thin porridge twice a day from a bottle. She has never given egg, fish or meat because she thought the baby was too young.
No acute malnutrition (MUAC 125 mm or more, no oedema). There is a feeding problem: breastfeeding less often than recommended, too few meals, thin porridge, no animal-source foods, and bottle use.
2. What do you advise?
Breastfeed as often as she wants, day and night; give mashed or finely chopped family food, half a cup 3 to 4 times a day plus 1 to 2 snacks, including egg, fish, meat or pulses and vitamin A-rich fruit and vegetables; use a cup instead of a bottle. Choose the two changes the mother feels able to make first, and follow up the feeding problem as your chart says.
M comes with diarrhoea for 3 days and no dehydration. He has no oedema; MUAC is 119 mm. His palms show some pallor. He has never had mebendazole.
What are his classifications?
Diarrhoea with no dehydration; moderate acute malnutrition (MUAC 115 to under 125 mm); anaemia (some palmar pallor).
What do you give, and when do you see him again?
Plan A with zinc for 14 days; iron (he is not on RUTF); mebendazole (over 1 year, none in 6 months); feeding assessment and counselling; assess for TB. Return at the earliest follow-up: 5 days if the diarrhoea is not improving, otherwise 14 days for anaemia, and 30 days for MUAC. Explain when to return immediately.
- MUAC under 115 mm or oedema of both feet is severe acute malnutrition; refer if complicated.
- Some palmar pallor: iron (not with RUTF) and mebendazole from 1 year; severe pallor: refer.
- Assess feeding in every child under 2 and in malnutrition, anaemia or HIV; compare with the age recommendations and agree one or two changes.
- Every carer leaves knowing when to return immediately and when to come for follow-up.
The sick young infant and the HIV-exposed infant
- Assess and classify a sick young infant (birth up to 2 months) with the WHO 7-sign algorithm for possible serious bacterial infection.
- Give pre-referral treatment, and know the WHO options when referral is not possible.
- Give an HIV-exposed infant prophylaxis, testing and follow-up until a final diagnosis.
About 3 million young infants die every year in the first 59 days of life, 98% of them in low- and middle-income countries, and sepsis, meningitis and pneumonia cause more than half a million of these deaths. Signs are often subtle and change fast: a baby who feeds poorly or moves less may be very ill. Young infants up to 2 months (0 to 59 days) are assessed with their own chart.
Possible serious bacterial infection: the 7 signs
- Not feeding well, or not able to feed at all.
- Convulsions.
- Fast breathing, 60 breaths per minute or more, in an infant aged 0 to 6 days (count for a full minute in a calm infant; repeat if high).
- Severe chest indrawing.
- Temperature 38 °C or above.
- Temperature below 35.5 °C.
- Movement only when stimulated, or no movement at all.
Source: WHO recommendations for management of serious bacterial infections in infants aged 0 to 59 days, 2024
| Signs | Classify | Action |
|---|---|---|
| Not able to feed at all, no movement at all, or convulsions | Critical illness | Pre-referral treatment; refer urgently. If referral is not possible: injectable ampicillin plus gentamicin for at least 10 days |
| Not feeding well, movement only when stimulated, temperature 38 °C or above or below 35.5 °C, or severe chest indrawing | Clinical severe infection | Pre-referral treatment; refer. If referral is not possible: oral amoxicillin for at least 7 days plus gentamicin for at least 7 days (or 2 days if 7 is not feasible) |
| Fast breathing as the only sign, age 0 to 6 days | Fast breathing in the first week | Refer. If referral is not possible: oral amoxicillin for at least 7 days |
| Fast breathing as the only sign, age 7 to 59 days | Fast breathing (pneumonia) | Oral amoxicillin for at least 7 days at home; close follow-up |
| Red or pus-draining umbilicus, or skin pustules | Local bacterial infection | Oral antibiotic; teach home treatment; follow up in 2 days |
| None of these | Severe disease or local infection unlikely | Home care advice |
Before referral: give the first IM dose of ampicillin and gentamicin, prevent low blood sugar (breastfeed, or give expressed breast milk or sugar water by cup or tube) and keep the infant warm on the way, ideally skin to skin with the mother. When the family cannot reach or accept referral, the outpatient regimens above need daily visits and a careful check on day 4. The one-page guide with doses is The sick young infant up to 2 months.
Also check every young infant for
| Problem | Severe (pink) | Action |
|---|---|---|
| Jaundice | Any jaundice under 24 hours of age, or yellow palms and soles at any age | Prevent low blood sugar, keep warm, refer urgently. Jaundice after 24 hours with normal palms and soles: home care, review in 1 day, refer if the infant is older than 14 days |
| Diarrhoea | Two of: moves only when stimulated or not at all, sunken eyes, skin pinch goes back very slowly | Plan C, or refer urgently with sips of ORS if there is another severe classification; keep breastfeeding |
| Feeding problem or low weight | Not able to feed (this is critical illness) | Not well attached, not suckling well, fewer than 8 breastfeeds in 24 hours, other foods or drinks, thrush or low weight: teach positioning and attachment, more frequent breastfeeds, follow up in 2 days (low weight in 14 days) |
The HIV-exposed infant
Ask about the mother's HIV status at every young infant visit. If she has never been tested, test her; if she is positive, the infant needs a virological test. Antibody tests cannot diagnose HIV in a child under 18 months, because the mother's antibodies can persist until then.
| Step | What WHO recommends |
|---|---|
| Mother | Lifelong ART for every pregnant or breastfeeding woman with HIV, started urgently; this is the most effective way to prevent transmission |
| Infant prophylaxis | Breastfed infant of a mother on ART: daily nevirapine for 6 weeks (4 to 6 weeks if replacement fed). High-risk infant (mother on ART less than 4 weeks at delivery, viral load above 1000 copies/mL, new infection in pregnancy or breastfeeding, or first diagnosed after birth): dual prophylaxis with zidovudine and nevirapine for 6 weeks, and a further 6 weeks if breastfed |
| Testing | Nucleic acid (virological) test at 4 to 6 weeks of age; some programmes add a test at birth. Point-of-care tests are recommended where available |
| Co-trimoxazole | From 4 to 6 weeks of age, until HIV is excluded by an age-appropriate test after breastfeeding has completely stopped |
| Feeding | Mothers with HIV should breastfeed for at least 12 months, and may continue up to 24 months or longer, with full support for ART adherence. Exclusive breastfeeding for the first 6 months |
| Final diagnosis | At 18 months of age, or 3 months after breastfeeding ends, whichever is later. Keep the child in follow-up until then |
An infant with a positive virological test needs ART and HIV care started without delay, with co-trimoxazole: see HIV testing and starting ART. In the IMCI sick child chart, an HIV-exposed or HIV-infected child with chest indrawing is referred, and every HIV-exposed child has feeding assessed (lesson 5).
Second case: an HIV-exposed infant at 6 weeks
Baby R, 6 weeks, comes for immunisation. His mother has been on ART since early pregnancy and her last viral load was suppressed. He is exclusively breastfed and has taken nevirapine since birth. He is well, feeding well, and his weight is normal for age. He has not had an HIV test.
A virological (nucleic acid) test, start co-trimoxazole prophylaxis, his immunisations, and completion of his 6 weeks of nevirapine. Assess feeding and praise exclusive breastfeeding.
2. How long does follow-up continue?
Until a final diagnosis: at 18 months, or 3 months after breastfeeding ends, whichever is later. Co-trimoxazole continues until HIV is excluded after breastfeeding has stopped completely.
Baby Q, 12 days old, is brought because she has fed poorly since yesterday. She is calm; her breathing rate is 64 per minute on two counts. There is no severe chest indrawing. Her axillary temperature is 38.4 °C. She moves only when stimulated. The umbilicus is clean. Her mother is HIV-negative.
How do you classify her?
Possible serious bacterial infection: she has several of the 7 signs (not feeding well, temperature 38 °C or above, movement only when stimulated). She can still feed and moves when stimulated, so she has clinical severe infection rather than critical illness. At 12 days, fast breathing on its own would be treated with oral amoxicillin, but here it comes with other signs, so the severe classification applies.
What do you do before she leaves the clinic?
Give the first IM doses of ampicillin and gentamicin, prevent low blood sugar (breastfeed or expressed milk by cup), keep her warm skin to skin, and refer urgently with a note.
The family cannot go to hospital. What then?
Explain the risks and keep encouraging referral. If referral is truly not possible, WHO recommends oral amoxicillin for at least 7 days plus gentamicin for at least 7 days (or for 2 days if 7 days of injections is not feasible), with daily contact and a careful check on day 4. Refer at once if she develops a sign of critical illness or is not improving.
- The 7 signs: not feeding well, convulsions, fast breathing at 0 to 6 days, severe chest indrawing, 38 °C or above, below 35.5 °C, movement only when stimulated or none.
- Critical illness or clinical severe infection: first-dose antibiotics, prevent low sugar, keep warm, refer. Outpatient regimens only when referral is impossible.
- Fast breathing alone at 7 to 59 days: oral amoxicillin for at least 7 days at home.
- HIV-exposed infant: infant prophylaxis, virological test at 4 to 6 weeks, co-trimoxazole from 4 to 6 weeks, breastfeeding with maternal ART, follow-up to a final diagnosis.
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Sources
- World Health Organization. Integrated Management of Childhood Illness (IMCI) chart booklet. 2014 (ISBN 9789241506823).
- World Health Organization. Revised WHO classification and treatment of pneumonia in children at health facilities: evidence summaries. 2014.
- World Health Organization. Guideline on management of pneumonia and diarrhoea in children up to 10 years of age. 2024.
- World Health Organization. WHO recommendations for management of serious bacterial infections in infants aged 0 to 59 days. 2024 (ISBN 9789240102903).
- World Health Organization. Guideline: managing possible serious bacterial infection in young infants when referral is not feasible. 2015 (ISBN 9789241509268).
- World Health Organization. Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. 2021 (ISBN 9789240031593).
- World Health Organization. WHO guideline on the prevention and management of wasting and nutritional oedema (acute malnutrition) in infants and children under 5 years. 2023.