Bilious vomiting (green bile) in a neonate or infant is a surgical emergency — malrotation with midgut volvulus can cause complete intestinal ischaemia within hours if untreated. It is incompatible with survival without emergency surgery. Never attribute bilious vomiting to feeding problems in neonates.
Pyloric stenosis peaks at 4–6 weeks (range 2–8 weeks), is more common in boys, and presents with projectile non-bilious vomiting after feeds, a visibly hungry child (not ill), and hypochloraemic hypokalaemic metabolic alkalosis on bloods. The "olive" is not always palpable. US is confirmatory.
DKA in previously undiagnosed T1DM can present as a flu-like illness with vomiting. In a vomiting child with polyuria, polydipsia, weight loss, fatigue or hyperventilation, check capillary glucose (and blood ketones where available). Do not diagnose DKA in primary care from glucose and urine ketones alone — NICE NG18 defines DKA by acidosis (pH <7.3 or bicarbonate <15 mmol/L) with ketonaemia >3 mmol/L or urine ketones ≥++, usually with glucose >11 mmol/L.
The timing and content of vomiting is the most important differentiating feature. "Redcurrant jelly" stool (bloodstained mucus) with colicky pain and vomiting in a 6–18 month old is intussusception until proven otherwise — this is a classic MRCGP and SCA scenario. Call 999 and document clearly.
Cyclical vomiting syndrome (CVS) is under-diagnosed — stereotyped episodes lasting 1–5 days with complete symptom-free periods between them, often triggered by stress or illness, frequently with a family history of migraine. Acute and preventive treatment, including any antiemetic, is specialist-led through the local paediatric pathway.
The NICE CG84 framework (no clinically detectable dehydration / clinical dehydration / shock) guides fluid management decisions in under 5s. Skin turgor ("tenting") is less reliable in obese children. The most reliable bedside signs are: dry mucous membranes, sunken eyes, tachycardia, and reduced skin perfusion. No single sign is reliable — interpret signs together.
Blood pressure is a late sign of dehydration in children — children compensate well and can maintain a normal BP until late. Tachycardia is an earlier and more sensitive marker. A normal BP does NOT rule out significant dehydration.
UTI can present with vomiting in infants without localising urinary symptoms, so test urine when UTI is clinically plausible (NICE NG224); infants under 3 months with suspected UTI need immediate paediatric referral. Most children with gastroenteritis do not need laboratory investigations (NICE CG84). Missing UTI leads to pyelonephritis, bacteraemia, and renal scarring.
DKA is increasingly diagnosed in primary care as T1DM incidence rises. In new-onset T1DM, the presentation mimics gastroenteritis — vomiting, abdominal pain, and malaise. Checking capillary glucose (and blood ketones where available) in any child with unexplained vomiting + any of polyuria, weight loss, polydipsia or excessive tiredness helps identify possible DKA early — refer immediately if suspected; do not try to confirm DKA in primary care.
Most children with gastroenteritis need no laboratory investigations (NICE CG84). Investigate selectively: urine when UTI is clinically plausible, capillary glucose and blood ketones when DKA is possible — targeted testing detects serious diagnoses (UTI, DKA) that are commonly missed.
Stool culture for routine gastroenteritis has a very low yield and rarely changes management. NICE CG84: perform stool microbiology if septicaemia is suspected, there is blood or mucus in the stool, or the child is immunocompromised; consider it after recent overseas travel, if diarrhoea has not improved by day 7, with diagnostic uncertainty or a suspected outbreak.
Intussusception has a classic presentation but also presents atypically — the "redcurrant jelly" stool is a late sign and often absent. The classic presentation is: age 6–18 months, sudden-onset severe colicky pain, pallor, drawn-up legs, vomiting (initially non-bilious, may become bilious), followed by periods of apparent wellness between episodes. Any vomiting infant with unexplained pallor and inconsolable crying should be referred immediately.
Next steps: see Gastroenteritis · Reflux in infants · Surgical problems in children · DKA
ORS via syringe at 5ml every 1–2 minutes works even when children are actively vomiting because small volumes leave the stomach before the vomiting reflex is triggered. A Cochrane review (2006) found ORS as effective as IV rehydration for mild-moderate dehydration and associated with shorter hospital stays. Demonstrating the technique to parents in the surgery dramatically improves compliance.
Metoclopramide (neurological/extrapyramidal adverse effects, MHRA) and domperidone (cardiac risks) are not routine antiemetics in children and not routine treatments for gastroenteritis or reflux; for reflux, NICE NG1 requires specialist paediatric agreement after other measures have been tried. MHRA (December 2019): domperidone is no longer licensed for children under 12 years or weighing under 35 kg; MHRA (2013): metoclopramide is contraindicated under 1 year and restricted to second-line specific indications in under 18s. NICE CG84 notes ondansetron can reduce vomiting and facilitate ORS but may increase diarrhoea, and does not recommend routine primary-care prescribing; it carries a dose-dependent QT-prolongation risk (MHRA), particularly with electrolyte imbalance from dehydration, so use only within the local paediatric pathway.
The 48-hour exclusion rule is a public health measure based on viral shedding patterns — norovirus and rotavirus are maximally contagious during and immediately after illness. Returning to school before 48 hours causes secondary cases in classrooms. Food handlers are advised to stay off work until 48 hours symptom-free (FSA guidance), and UKHSA recommends the same for children in communal settings.
Rotavirus vaccination (UK schedule since 2013) is the main intervention for preventing severe rotavirus disease; it is preventative and does not treat current illness. Checking vaccination status during an acute consultation is a brief but valuable quality intervention.
Written safety-net advice reduces ED re-attendance in gastroenteritis (clinical practice). Specific, actionable instructions ("call 999 if vomit turns green") are more effective than generic advice ("come back if worried"). Document that safety-netting was provided.
Gastroenteritis-triggered haemolytic uraemic syndrome (HUS) occurs 5–10 days after E. coli O157 infection — vomiting/diarrhoea resolves, then child develops pallor, reduced urine output, and bruising (microangiopathic haemolytic anaemia + renal failure). Parents should be warned about this specifically if bloody diarrhoea is present. Send stool culture and review in 1 week. If STEC is suspected or confirmed, do not give antimotility agents and seek specialist/public-health advice on monitoring for HUS.