💉 Heavy Menstrual Bleeding

RCGP SCA Algorithm — UK Primary Care

NICE NG88NICE NG12CoSRH UKMECBSG iron10-min consult
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Heavy Menstrual Bleeding (Menorrhagia) — New Presentation History-led assessment per NICE NG88 · FBC in all · examine and scan when indicated · intermenstrual, postcoital and postmenopausal routes · start treatment today
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⚡ Snapshot. The whole pathway on one page: act now, triage, classify, treat today and safety-net. The Steps tab holds the detail.

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1
Safety

Red Flags — The Emergency, the Cancer Routes and Pregnancy

Heavy menstrual bleeding (HMB) is defined by its effect on the woman's quality of life, not by a measured volume (NICE NG88). Before classifying it as HMB, exclude the emergency, pregnancy and bleeding that is not menstrual at all.

Haemodynamic compromise Torrential bleeding with tachycardia, hypotension, syncope or collapse → 999 Emergency admission to gynaecology
Heavy bleeding with a positive pregnancy test Miscarriage or ectopic pregnancy until proven otherwise → Same-day early pregnancy unit; 999 if shoulder-tip pain, collapse or peritonism — see the bleeding in pregnancy algorithm
Postmenopausal bleeding aged 55 or over Unexplained and not attributable to HRT → Suspected cancer endometrial suspected cancer pathway referral (NICE NG12). Under 55 → consider the same referral; do not falsely reassure. Bleeding on HRT → bleeding on HRT algorithm
Abnormal-looking or abnormal-feeling cervix Contact bleeding, ulcer or mass → Suspected cancer consider a suspected cervical cancer pathway referral (colposcopy) — a normal recent screening result does not exclude it
Pelvic or abdominal mass not obviously fibroids, or ascites → Suspected cancer gynaecology suspected cancer pathway referral (NICE NG12)
Iron-deficiency anaemia out of proportion to the bleeding Do not attribute it to periods reflexively → offer quantitative FIT and refer on the colorectal suspected cancer pathway if ≥10 µg Hb/g (NICE NG12); check coeliac serology
Symptomatic anaemia Breathless at rest, chest pain, syncope, Hb very low with symptoms → Same-day assessment for transfusion or IV iron
Bleeding disorder features Heavy since menarche, epistaxis, gum bleeding, easy bruising, post-partum, post-dental or post-surgical bleeding, family history → discuss testing with haematology (von Willebrand disease)

NICE NG88 deliberately defines HMB by its impact on physical, emotional, social and material quality of life, and says measuring blood loss is not needed. The red flags above are not HMB at all, or they are HMB with a dangerous cause: pregnancy complications, endometrial, cervical and ovarian cancer, and colorectal cancer presenting as iron deficiency.

Postmenopausal bleeding is a different presentation: NG12 (updated April 2026) asks for a suspected cancer pathway referral at 55 or over when it is unexplained and not due to HRT, and to consider referral under 55. Von Willebrand disease is the commonest inherited bleeding disorder and is substantially under-diagnosed in women with lifelong HMB.

2
Diagnose

History — Impact, Pattern and What Else Is Going On

Impact (the definition)
"What does a heavy day look like?" Flooding through clothes or bedding, clots, changing protection every 1–2 hours, double protection, night-time changes, days off work or school, planning life around periods
Pattern
Regular heavy periods → fibroids, adenomyosis, coagulopathy or no cause found. Irregular, intermenstrual or postcoital bleeding → anovulation, polyps, hyperplasia, cervical or endometrial pathology, infection — a different route (step 3)
Intermenstrual or postcoital bleeding
Cervical screening status, STI risk (chlamydia), cervical ectropion or polyp, hormonal contraception (unscheduled bleeding), endometrial pathology. Persistent → examination, STI test and outpatient hysteroscopy (see step 3)
Pain & pressure
Dysmenorrhoea and deep dyspareunia → adenomyosis or endometriosis; bulk, pressure or urinary frequency → fibroids
Anaemia symptoms
Fatigue, breathlessness, palpitations, poor concentration, restless legs, pica, hair loss
Bleeding disorder screen
Heavy since menarche; nosebleeds, gum bleeding, bruising; bleeding after childbirth, dental extraction or surgery; family history
Drugs & devices
Copper IUD, anticoagulants (DOACs in particular) and antiplatelets, SSRIs, tamoxifen, missed or erratic hormonal contraception, herbal remedies
Thyroid & endocrine
Only if symptoms or signs of thyroid disease; irregular cycles with hirsutism or acne → PCOS; obesity with infrequent heavy bleeding → endometrial hyperplasia risk
Pregnancy plans & contraception
Ask early — it decides the treatment options (step 7). Current contraception, UKMEC risk factors (migraine with aura, VTE history, smoking over 35, BMI, BP)
Endometrial risk factors
Persistent intermenstrual bleeding, BMI 30 or over or PCOS with infrequent heavy bleeding, unopposed oestrogen, tamoxifen, Lynch syndrome, treatment failure

NG88 is history-led: the history decides whether examination and investigations are needed at all, and whether treatment can start today. Distinguishing regular heavy bleeding from irregular, intermenstrual or postcoital bleeding is the single most important step, because the latter needs a look at the cervix and often imaging or hysteroscopy rather than empirical treatment alone.

3
Diagnose

Examination and Imaging — When NG88 Says So

Pregnancy test
If any chance of pregnancy — before treatment and always before an LNG-IUS
Observations
Pulse and BP if bleeding is heavy now or symptoms of anaemia; pallor
Abdominal & pelvic exam
Offer (with chaperone and consent) if intermenstrual or postcoital bleeding, pelvic pain or pressure, suspected structural disease, or before fitting an LNG-IUS. In uncomplicated HMB with no other symptoms, drug treatment can start without a pelvic examination
Speculum
Look at the cervix in anyone with intermenstrual or postcoital bleeding: polyp, ectropion, cervicitis, abnormal cervix (→ consider suspected cervical cancer pathway). Take chlamydia/gonorrhoea NAAT swab if any STI risk; check cervical screening is up to date
Ultrasound (TVUS)
Pelvic ultrasound if the uterus is palpable abdominally, a mass is suspected, or examination is inconclusive or difficult; transvaginal ultrasound for suspected adenomyosis (dysmenorrhoea, bulky tender uterus). Persistent intermenstrual bleeding → outpatient hysteroscopy, not ultrasound. Treatment failure alone is not an ultrasound criterion (NG88)
Hysteroscopy
Outpatient hysteroscopy (gynaecology) if the history suggests submucosal fibroids, polyps or endometrial pathology — persistent intermenstrual bleeding or endometrial risk factors. Do not use blind endometrial biopsy as the routine test

NG88 moved away from routine examination and ultrasound for all women: in uncomplicated HMB treatment can start on the history. Examination and imaging are targeted at the features that suggest structural or sinister pathology. Hysteroscopy is preferred to ultrasound alone where endometrial pathology is suspected, because it allows direct sampling of focal lesions.

4
Diagnose

Investigations — FBC in Everyone, the Rest Targeted

All women
FBC in parallel with starting treatment (NICE NG88)
Ferritin
NG88 (updated July 2026) no longer advises against ferritin testing. Consider ferritin where iron deficiency is suspected despite a normal haemoglobin, anaemia is present, symptoms are disproportionate, or the result will change iron treatment
Coagulation
HMB since menarche with a positive bleeding history or family history → discuss with haematology; von Willebrand screen per local pathway (levels vary with stress, pregnancy and oestrogen; a routine clotting screen is not sensitive)
Thyroid
TFTs only if symptoms or signs of thyroid disease — not routinely
Iron-deficiency anaemia
Ask whether the bleeding explains it. Quantitative FIT and coeliac serology if disproportionate, GI symptoms, or other concern (see the anaemia algorithm)
Not routinely
Hormone tests (FSH, LH, oestradiol), progesterone, routine TFTs, routine coagulation screens, blind endometrial biopsy

Iron deficiency is very common in HMB and frequently under-treated; NICE removed its advice against routine ferritin testing in July 2026 for this reason. Hormone profiles do not help: cycle hormones are normal in most women with HMB and do not guide treatment.

5
Diagnose

Differential Diagnosis — Structural, Systemic or No Cause Found

No structural cause
Endometrial dysfunction
Commonest — regular heavy periods with a normal examination. Treat on the history
Fibroids
Leiomyomas
Regular HMB, bulk or pressure, palpable or irregular uterus; submucosal fibroids bleed most
Adenomyosis
Bulky tender uterus
HMB with dysmenorrhoea and deep dyspareunia; often over 40 and parous
Polyps & hyperplasia
Endometrial pathology
Intermenstrual or irregular bleeding, obesity, PCOS, tamoxifen, unopposed oestrogen
Ovulatory dysfunction
PCOS · perimenopause · thyroid
Irregular, unpredictable heavy bleeds — see the irregular periods algorithm
Coagulopathy & drugs
vWD · anticoagulants · copper IUD
Lifelong HMB with bleeding history; new HMB after starting a DOAC or copper IUD
Cervical & infective
Postcoital / intermenstrual
Chlamydia, ectropion, cervical polyp, cervical cancer
Pregnancy-related
Miscarriage · retained products
Always test if any chance of pregnancy

Classifying the bleeding as structural (polyp, adenomyosis, leiomyoma, malignancy/hyperplasia) or non-structural (coagulopathy, ovulatory, endometrial, iatrogenic, not yet classified) follows the FIGO PALM-COEIN approach. For most women in primary care no structural cause is found and treatment starts on the history.

6
Refer

Referral Criteria

999
Haemodynamic compromise, collapse, suspected ruptured ectopic
Same-day
Positive pregnancy test with heavy bleeding or pain (early pregnancy unit); symptomatic severe anaemia
Suspected cancer · NICE NG12
Postmenopausal bleeding aged 55 or over not attributable to HRT (endometrial); consider under 55. Abnormal cervix (cervical, consider). Pelvic mass not obviously fibroids, or ascites (ovarian). Iron-deficiency anaemia with FIT ≥10 µg Hb/g (colorectal)
Gynaecology (consider referral)
Treatment failure after an adequate trial (usually around 3 months, 6 cycles for an LNG-IUS); fibroids 3 cm or more or distorting the cavity; persistent intermenstrual bleeding or endometrial risk factors (outpatient hysteroscopy); suspected adenomyosis not responding; woman wishing to discuss surgery
Haematology
Suspected inherited bleeding disorder; HMB on anticoagulation needing a joint plan
Sexual health / colposcopy
Persistent postcoital bleeding with a normal-looking cervix → gynaecology; screening overdue → arrange screening

Most HMB is managed in primary care. Referral is for the woman whose bleeding has a sinister or structural cause, who has not responded to first-line treatment, or who wants to consider surgical options (endometrial ablation, myomectomy, uterine artery embolisation, hysterectomy) — NG88 asks that these are discussed rather than offered only after failed medication.

7
Treat

Start Treatment Today — Split by Pregnancy Plans

Not trying to conceive, no structural cause or fibroids <3 cm
LNG-IUS 52 mg First-line
NG88 first-line; also contraceptive and reduces pain. Explain irregular bleeding is common initially and allow at least 6 cycles. Fit after a pregnancy test (local fitter if not in-house)
LNG-IUS declined or unsuitable — non-hormonal
Tranexamic acid ± NSAID
Tranexamic acid usual adult dose: 1 g three times a day for up to 4 days from the start of bleeding, maximum 4 g a day (SPC); avoid with active or past thromboembolism. Mefenamic acid usual adult dose: 500 mg three times a day during bleeding (SPC); avoid if NSAID-sensitive asthma, peptic ulcer or significant renal impairment
LNG-IUS declined or unsuitable — hormonal
CHC or cyclical progestogen
Combined hormonal contraception if UKMEC 1–2 (can be taken continuously or tailored). Cyclical oral progestogen: norethisterone usual adult dose 5 mg three times a day from day 5 to day 26 of the cycle (SPC; not contraceptive). A progestogen-only pill or injectable gives contraception and may lighten bleeding, but NG88 does not list it as an HMB treatment and unscheduled bleeding is common
Trying to conceive
Tranexamic acid ± mefenamic acid
Non-hormonal options only; take from the onset of bleeding; stop if pregnancy is confirmed
IronTreat iron deficiency now — oral iron once daily or on alternate days (for example ferrous sulfate 200 mg, per SPC and local formulary) until Hb normalises, then a further 3 months to replenish stores; check Hb at about 2–4 weeks. Consider iron replacement for confirmed iron deficiency even with a normal Hb
AnticoagulatedHMB on a DOAC — do not simply stop it: discuss with the prescriber or haematology (a switch of agent is sometimes considered); LNG-IUS and tranexamic acid need individual risk discussion — tranexamic acid is generally avoided with recent VTE
Copper IUDCopper IUD causing HMB — offer a change to an LNG-IUS or another method
ReviewReview in about 3 months (6 cycles for an LNG-IUS); earlier if severe, anaemic or not tolerating treatment

Next steps: see Heavy menstrual bleeding · Iron deficiency & iron-deficiency anaemia · Contraception

NG88 makes the 52 mg LNG-IUS the first treatment to consider when there is no structural abnormality, or only fibroids under 3 cm not distorting the cavity, or suspected adenomyosis; it is the most effective medical option for most women. If it is unsuitable or declined, non-hormonal (tranexamic acid, NSAIDs) and hormonal (combined hormonal contraception, cyclical oral progestogens) options are offered. Treatment should start at the first consultation, in parallel with any investigation.

The hormonal options are contraceptive and cannot be used while trying to conceive, so the pregnancy-plans question comes first. Iron deficiency is treated alongside: correcting it often improves fatigue more than controlling the bleeding.

8
Lifestyle

Self-Care and Shared Decision-Making

Bleeding diary Simple record of heavy days, flooding, clots and impact — the baseline for judging treatment.
Iron-rich diet Red meat, pulses, dark green vegetables, fortified cereals; vitamin C with meals; tea and coffee away from iron tablets.
Weight Weight management where BMI is raised reduces anovulatory bleeding and endometrial risk.
Information Explain the options, likely benefits, side effects and the time each needs to work; offer written information (NICE decision aids).
Work and school Practical support and fit notes when bleeding or anaemia affects function.
Contraception Remind that tranexamic acid, NSAIDs and cyclical norethisterone are not contraceptive.

NG88 emphasises shared decision-making: the woman's priorities (contraception, fertility, avoiding hormones, avoiding surgery) determine the choice between options of similar effectiveness, and a diary gives both of you an objective way to judge the response.

9
Safety

Follow-Up and Safety-Netting

Safety-net 999
Soaking through pads every few minutes, fainting or collapse, severe pain with a positive pregnancy test or shoulder-tip pain
Safety-net same-day
Very heavy bleeding with dizziness, breathlessness or palpitations; positive pregnancy test with bleeding or pain; leg swelling, chest pain or breathlessness on tranexamic acid or CHC
2–4 weeks
Hb response to iron if anaemic; results of FBC, ferritin and any imaging acted on
About 3 months
Impact and diary review; switch or escalate if inadequate (LNG-IUS: allow at least 6 cycles); refer if failure or new features
Re-assess if
New intermenstrual or postcoital bleeding, new pelvic pain or mass, bleeding after the menopause, or anaemia not responding

Treatment failure and persistent anaemia are the commonest reasons for missed structural pathology; planned review at about 3 months, with the diary and the FBC, catches both. Women using tranexamic acid or combined hormonal contraception should know the symptoms of VTE.

Educational use only. Based on: NICE NG88 (Heavy menstrual bleeding: assessment and management, 2018, updated July 2026), NICE NG12 (Suspected cancer: recognition and referral, updated April 2026), NICE CKS Menorrhagia, CoSRH UK Medical Eligibility Criteria for contraceptive use (UKMEC) and CoSRH intrauterine contraception guidance, BSG guideline for the management of iron deficiency anaemia in adults (2021), UK Haemophilia Centre Doctors' Organisation guidance on von Willebrand disease, product SPCs (tranexamic acid, mefenamic acid, norethisterone, levonorgestrel 52 mg intrauterine system). Pregnancy, postmenopausal bleeding and bleeding on HRT follow separate pathways. Check doses in the SPC and your local formulary. Not a substitute for clinical judgement.