Posterior vitreous detachment (PVD)
The commonest cause of new flashes and floaters from middle age onwards; the vitreous gel separates from the retina. Retinal tear, detachment, vitreous haemorrhage and inflammation must be excluded by dilated examination. Label as uncomplicated only after an adequate dilated retinal examination: normal acuity, no field loss, no shower, and no tear
Retinal tear
A clinically important minority of patients with acute symptomatic PVD have a retinal tear; risk varies with the presenting population and features such as vitreous haemorrhage, pigment, trauma and reduced vision. Treated by ophthalmology with laser retinopexy or cryotherapy where appropriate
Retinal detachment
Fluid passes through the tear and lifts the retina: a spreading shadow or curtain, ± reduced vision. Needs urgent vitreoretinal surgery; timing depends on whether the macula is still attached
Vitreous haemorrhage
Sudden "red haze", many dark floaters, reduced vision; poor or absent red reflex. Causes: proliferative diabetic retinopathy, retinal vein occlusion, retinal tear/detachment, trauma, posterior vitreous detachment; less commonly retinal vasculitis or haematological disease. Anticoagulation may increase severity. Acute vitreous haemorrhage with flashes/floaters needs same-day ophthalmological assessment even if the patient is anticoagulated or has known diabetes
Posterior uveitis / vitritis
Floaters with blurred vision ± pain, photophobia, red eye; may be linked to systemic inflammatory disease or infection
Benign vitreous floaters
Long-standing, stable spots or strands; normal vision and fields; no flashes. Reassure, but any change in character means reassessment
Migraine aura
Positive spreading visual disturbance affecting both eyes' fields, developing over at least 5 minutes and lasting 5–60 minutes, usually followed by headache; fully reversible (NICE CG150). First or atypical aura, persistent deficit, weakness/speech disturbance or older age without previous migraine → consider urgent neurological/stroke assessment
Macular causes
Central distortion or scotoma: macular hole, vitreomacular traction, cystoid macular oedema, wet AMD, retinal vascular event, macula-involving detachment → urgent ophthalmology (macular/medical-retina pathway; suspected wet AMD within 1 working day, NICE NG82; same day if sudden or with reduced vision)
Other mimics
Occipital lobe lesions and seizures (stereotyped coloured shapes), retinal migraine (monocular, diagnosis of exclusion), phosphenes on eye movement from optic neuritis