Neurodevelopmental · Full case

Autism in Children

NICE CG128/CG170DSM-5CKS 2023
A
Autism in Children · Clinical Reasoning Framework v2
GP & SCA · NICE CG128/CG170 (2022) · DSM-5 · CKS Autism 2023
1 in 57UK autism prevalence — 2022 NHS Digital estimate
2 domainsDSM-5: social communication + restricted/repetitive behaviours (both required)
4.6 yearsAverage later diagnosis in girls vs boys — masking/camouflaging delays recognition
NEVER"Wait and see" — NICE CG128/CG170: refer if autism suspected; do not delay for speech alone
80%Autistic children with sleep difficulties — most common GP pharmacological intervention
50–70%Autism + ADHD comorbidity rate
1 in 3Autistic people who develop epilepsy (higher risk than general population)
HearingFormal audiology before autism referral — hearing loss mimics and co-occurs with autism
📋 Clinical Stem — Developmental Concerns in a Toddler
Parents present with concerns about their 3.5-year-old's communication, social engagement, and rigid behaviours
Luke and Jasmine Fletcher attend with their son Ethan, aged 3 years 6 months. They are concerned because Ethan has very few words (10–15 single words; not combining), does not point to share interest, and rarely looks at other children. He becomes extremely distressed if his routine is changed — he insists on the same route to nursery, the same colour plate, and the same bedtime sequence. He lines up his toy cars in precise order and becomes very upset if they are moved. He responds to his name inconsistently. His paternal grandmother says "all boys talk late" and both sets of grandparents think the parents are worrying unnecessarily. The parents feel guilty for "labelling" him but are distressed by his distress and the daily impact on family life.
This stem tests recognition of the two DSM-5 autism domains (social communication deficits + restricted/repetitive behaviours), NICE CG128/CG170 referral obligations, and the ability to support anxious parents through the referral process without "wait and see" advice. The GP must also screen for hearing loss (formal audiology before referral), identify red flag developmental markers, and address the grandparents' dismissive stance without dismissing their role.
Scenario A — Older Child, Missed in Early Childhood 9-year-old girl, academically high-achieving, referred by school SENCO. "Meltdowns" at home after school (emotional regulation overload), intense special interests (horses), follows rigid social rules, does not understand implied social rules. Autism in girls: later diagnosis due to masking/camouflaging. School attainment does not exclude autism — many autistic girls mask successfully in academic settings.
Scenario B — Regression Pattern 2-year-old, developed normally to 18 months (10 words), then stopped talking and stopped making eye contact. Apparent regression — may indicate Rett syndrome (girls, rare but important), childhood disintegrative disorder, or autistic regression (common variant; 25–30% of autistic children show regression). Urgent referral to paediatrics + EEG if regression pattern.
Scenario C — Autism + ADHD Comorbidity 7-year-old boy with confirmed autism diagnosis now struggling at school with inattention, impulsivity, and inability to wait his turn. ADHD comorbidity (50–70% of autistic children). Paediatric psychiatry review for ADHD assessment. Methylphenidate may be less effective in autism — atomoxetine or guanfacine as alternatives.
Scenario D — Sleep Disturbance in Autistic Child Parents of a 5-year-old autistic child attend: child sleeps only 4–5 hours, falls asleep at midnight, wakes multiple times. Sleep disorder is universal in autism — biological (melatonin circadian rhythm dysregulation) + behavioural factors. Melatonin (Slenyto — licensed for autism sleep in children aged 2–18) is the first-line pharmacological treatment.
Scenario E — Parental Distress and Sibling Autism Parents of a 2-year-old whose older sibling has autism. They have noticed similar early signs (not pointing at 12 months, not babbling). Sibling recurrence risk ~20%. Earlier referral warranted given family history. Parent mental health: PHQ-9 for maternal depression. Connect to National Autistic Society and local autism support groups.
Key variables to adapt for Age at presentation (0–19), sex (girls mask longer), cognitive ability (autism without intellectual disability vs with ID), presence of regression (urgent referral), comorbidities (ADHD, anxiety, epilepsy, GI), family history of autism, language level, and school involvement.
Steps:
1
Step 1
History Taking — Developmental History · DSM-5 Domains · Red Flags · ICE · Family Context
collapse
The developmental history is the diagnostic cornerstone of autism assessment. The GP's role is not to diagnose autism — that requires a multi-disciplinary team with structured tools (ADOS-2, ADI-R). The GP's role is to recognise the pattern, refer promptly, and never give "wait and see" advice. NICE CG128/CG170 (2022): if autism is suspected, refer to an autism assessment service — do not delay because the child makes eye contact, is verbal, or has some social skills. Early diagnosis enables early intervention, which significantly improves outcomes.
🎓 Consultation opener — acknowledge the courage it took to come
"Thank you for coming in — I can hear that you have been worried about Ethan for a while and I want to give you the time to tell me everything you have noticed. Parents know their children better than anyone, and your observations are the most important information I have."
Parental concern in autism consultations is frequently met with dismissal. This opening explicitly validates parental expertise before any clinical questions — which is both therapeutically correct and diagnostically sound.
1A — Developmental history and DSM-5 domain screening
Question to askWhy it matters clinicallyChanges what?
🟢 OPEN QUESTION"Tell me about Ethan in his own world — what is he like at home, what does he enjoy, how does he play, and what have you noticed that has made you worry?" The parent's spontaneous narrative reveals the two DSM-5 autism domains without clinical prompting. Parents of autistic children typically describe: preferring to play alone; not pointing to share interest; intense focus on specific topics or objects; rigid routines; unusual responses to sensory experiences. Allow the narrative to run — the diagnostic picture emerges from the quality of engagement described, not just the presence or absence of words.In SCA: a candidate who immediately asks "does he make eye contact?" has led the diagnostic conversation misleadingly — autistic children often make eye contact with familiar people. Eye contact alone neither confirms nor excludes autism. DSM-5 domains spontaneously revealedReferral urgency determined by pattern
Domain A: Joint attention — pointing to share"Does Ethan point to things to show you — not to ask for things, but just to share his excitement? Does he look where you point? Does he show you things he has found?"Proto-declarative pointing (pointing to share interest, not to request) absent by 14 months is the most specific early autism marker. By 12–14 months, typically developing children consistently point to share interest and follow a pointing gesture. Many autistic children do point (especially to request), so the absence of sharing-pointing is more specific than pointing per se.The M-CHAT-R/F is a validated screening tool for 16–30-month-olds. NICE CG128/CG170 cautions: do not use M-CHAT alone to exclude autism. A positive M-CHAT should accelerate, not replace, referral.Absent joint attention: core autism markerAbsent by 14 months: referral indicated
Domain A: Social reciprocity and peer interest"Is Ethan interested in other children? Does he watch them, try to join in, or does he prefer adults or playing alone? Does he initiate social games like peek-a-boo or chase?"Reduced interest in peers is a cardinal feature. Many autistic children prefer solitary play, parallel play without engagement, or interaction with adults on their own terms. The quality of social reciprocity — mutual engagement, back-and-forth play, reading others' feelings — is more diagnostically important than the frequency of social contact.Autism is not simply "being shy." Shyness involves wanting social contact but being inhibited. Autism involves a qualitatively different pattern of social motivation and social understanding.Reduced peer interest vs shynessBoth DSM-5 domains required for diagnosis
Domain B: Restricted repetitive behaviours and insistence on sameness"Are there things that have to be done exactly the same way every time — a specific route, a specific order, specific words at bedtime? What happens if it changes?"Insistence on sameness and restricted/repetitive behaviours are Domain B of DSM-5 — required alongside social communication deficits for diagnosis. Manifests as: exact routines that cannot be modified; intense distress at unexpected change; repetitive motor mannerisms; intense, narrow special interests; unusual sensory responses (covering ears, seeking strong sensory input, food texture sensitivities).Many parents describe these as "strong-willed" or "sensitive" rather than as a pattern. The GP's role is to recognise Domain B, not just language delay.Domain B present: both domains metNICE CG128/CG170: refer if both domains suspected
Hearing screen status"Has Ethan had a formal hearing test — not just the neonatal screen, but a full audiology assessment? Has anyone ever been concerned about his hearing?"Hearing loss is a mandatory exclusion before autism referral. The neonatal hearing screen detects severe/profound loss but may miss mild-moderate hearing loss. Otitis media with effusion ("glue ear") at 3–5 years causes fluctuating hearing loss that significantly impacts language development and social communication. Audiology should be arranged concurrently with — not before — autism referral.Autism and hearing loss can coexist — hearing loss does not exclude autism. Both need addressing.Formal audiology concurrent with autism referralHearing loss vs autism vs both
Regression or developmental plateau"Did Ethan develop normally and then seem to lose skills — words, social responses, things he could do before? At what age? How quickly?"Developmental regression in 25–30% of autistic children — typically around 18–24 months. However, regression also warrants urgent medical review to exclude: Rett syndrome (girls; MECP2 mutation; stereotyped hand movements), Landau-Kleffner syndrome (acquired epileptic aphasia), childhood disintegrative disorder, and metabolic conditions. Abrupt, rapid regression at any age requires urgent paediatric assessment with EEG.Rett syndrome is rare but critical in girls with developmental regression — loss of purposeful hand use and hand-wringing movements are pathognomonic. Immediate genetics and paediatric neurology.Rapid regression: urgent paediatric + EEGRett syndrome screen if girls
Sleep history"How does Ethan sleep? How long to fall asleep? Does he wake in the night? What time does he wake in the morning?"80% of autistic children have significant sleep difficulties — delayed sleep onset (melatonin circadian rhythm dysregulation), night waking, early morning waking. Sleep deprivation worsens all autism-related difficulties: emotional regulation, sensory sensitivity, cognition, and behaviour. Slenyto (melatonin prolonged-release; NICE BNFc) is licensed specifically for autism sleep in children aged 2–18.Parent sleep deprivation from a child with autism is also a safeguarding risk. Carers' assessments can be offered through social services.Sleep difficulties: Slenyto (melatonin PR)Parental sleep deprivation; carer wellbeing
Language milestones and communicative use"How many words does Ethan have? Is he putting words together? Does he use language to chat — or mainly to ask for things? Does he repeat phrases from TV?"Language delay is a common presenting concern but is not required for autism diagnosis — many autistic children have typical or advanced language. More diagnostically relevant: is language used communicatively? Echolalia (repeating TV scripts, delayed echolalia) is very common. Lack of conversational reciprocity is more specific than vocabulary count alone.A child with 200 words who uses them only to label objects and request items — without chatting, sharing feelings, or asking questions — has a social communication profile consistent with autism regardless of vocabulary size.Communicative vs non-communicative languageSALT referral concurrent with autism referral
Sensory profile"Is he unusually sensitive to sounds, lights, textures, or tastes? Does he seek certain sensory experiences — spinning, crashing, eating non-food items?"Sensory processing differences are included in DSM-5 Domain B criteria — present in approximately 90% of autistic people. Sensory overload (fluorescent lighting, background noise, physical contact) causes significant distress and drives the "meltdowns" families find most challenging. Understanding sensory triggers is essential for family management and school accommodations.OT with sensory integration specialisation provides a sensory profile and diet tailored to the child. Pica (eating non-food items) warrants a lead level check.Sensory profile: OT referralSchool accommodations; EHCP application
Family history and parental wellbeing"Does anyone in the family have autism, ADHD, language disorder, or social anxiety? How are you both coping? How is this affecting family life?"Autism is strongly heritable — first-degree relative recurrence risk ~20%. A family history increases pre-test probability. Crucially: parental mental health in the context of an undiagnosed autistic child is often severely impacted. PHQ-9 for both parents. Signpost to National Autistic Society (autism.org.uk) before diagnosis is confirmed.Parents of autistic children have higher rates of depression, anxiety, and burnout. Support before diagnosis is a clinical need, not a nice addition.Parental mental health: PHQ-9NAS referral; carer assessment
1B — Red flags: urgently refer or investigate
🚨

Red Flags in Developmental Assessment

Red flagWhy dangerousAction
Loss of previously acquired words or social skills at any age (regression)May indicate Rett syndrome, Landau-Kleffner syndrome (epileptic aphasia), childhood disintegrative disorder, or metabolic condition. Regression must be investigated urgently — it is not a normal variant of development.Urgent paediatrics + EEG within 2 weeks
No babbling by 12 months, no single words by 16 months, no two-word phrases by 24 monthsNICE CG128/CG170 developmental milestone thresholds warranting urgent referral — regardless of whether autism is suspected. Not "wait and see."Urgent paediatrics; audiology; SALT
New-onset seizures in a child with autism or developmental delay1 in 3 autistic people develop epilepsy. New seizures trigger urgent EEG and paediatric neurology referral.Urgent EEG + paediatric neurology
Stereotyped hand movements (wringing, washing) in a girl with developmental regressionRett syndrome — MECP2 mutations in girls; developmental regression + loss of purposeful hand use + hand-wringing = pathognomonic. Distinct from autism; requires genetics and neurology.Urgent genetics + paediatric neurology
Macrocephaly (head circumference above 98th centile) with developmental concernsAssociated with PTEN mutations (autism + macrocephaly + cancer risk), hydrocephalus, and Sotos syndrome.Plot head circumference; genetics referral
🛡️

Safeguarding Considerations

👪 Parental Mental Health
  • PHQ-9 and GAD-7 for both parents at the referral appointment — parental depression is a safeguarding concern
  • Carer's assessment (Social Services) — legal entitlement; unlocks respite care, financial support, community support
  • Sibling wellbeing — neurotypical siblings may have their own unmet needs when all family resources go to the autistic child
🏫 Educational Risk
  • Autistic children are significantly more likely to be excluded from school — exclusion disproportionately affects undiagnosed autistic pupils
  • EHCP requires diagnosis — delayed diagnosis means delayed educational support; start the process early
  • Bullying and victimisation: autistic children are at significantly higher risk — ask directly about school safety at every review
💊 Medication Safety
  • Antipsychotics (risperidone, aripiprazole): risk of weight gain, metabolic effects, EPS, tardive dyskinesia — specialist initiation only; GP should never initiate for autism without specialist recommendation
  • Melatonin: safe for autism sleep; Slenyto is the licensed preparation; document indication
  • ADHD medications in autistic children: methylphenidate may be less effective and worsen anxiety — specialist decision
🌍 Cultural and Diagnostic Barriers
  • Autism is underdiagnosed in Black and minority ethnic communities — cultural explanations, less familiarity, and referral bias
  • Girls diagnosed on average 4.6 years later than boys — masking/camouflaging; a quiet, well-behaved girl may be labelled "shy" for years
  • Grandparents and extended family may resist the diagnostic process — engage sensitively while maintaining focus on the child's needs
If safeguarding concerns: Parental mental health crisis affecting child safety → children's social care. Educational exclusion without EHCP → SENCO involvement urgently. Regression → emergency paediatric referral today. Family refusing referral → document advice given and maintain relationship.
1C — PMH · Drug history · Family history
🧬 PMH / Family history
FactorWhy it mattersImpact on management
Prematurity / low birth weightHigher autism prevalence; may co-occur with other neurodevelopmental differencesFull neurodevelopmental assessment; awareness of comorbid motor, sensory, and cognitive difficulties
Genetic syndromes (Fragile X, tuberous sclerosis, PTEN, Down)All associated with higher autism prevalence. Fragile X: most common inherited ID cause. Tuberous sclerosis: skin findings + epilepsy + autismGenetics referral. Tuberous sclerosis: MRI brain + renal ultrasound + ophthalmology. Fragile X: CGG repeat testing
Epilepsy history1 in 3 autistic people develop epilepsy; conversely, children with epilepsy have higher autism ratesEEG surveillance. Paediatric neurology. Valproate: counsel girls about teratogenicity from early adolescence
Family history of autism, ADHD, dyslexia, social anxietyAll cluster in families (shared genetic architecture). Parents may describe themselves as "a bit like him" — diagnostically and therapeutically valuableFamily history increases probability; paternal/maternal undiagnosed autism common
Recurrent otitis media / grommets historyFluctuating hearing loss from glue ear at critical language learning period mimics autism or co-occursAudiology referral; ENT for persistent OME. Autism diagnosis may change after hearing is optimised
💊 Social and developmental context
FactorWhy it mattersImpact
Pre-school / nursery observationsPre-school teachers see the child in group settings revealing social communication and behaviour not visible at home. SENCO involvement is part of the pathwayRequest written nursery/school observations for referral letter. Ask school to initiate SEND Support Plan now.
BilingualismBilingual children may have smaller vocabularies in each language individually — this can be mistaken for language delay. Autism features transcend language — social communication deficits and restricted behaviours present in all languagesSALT in both languages. Bilingualism is not a cause of language delay or autism — do not advise switching to English only.
Screen time patternsAutistic children often have intense interest in devices for regulation, comfort, and learning. Screen time is frequently blamed for language delay but is not causativeAdvise balanced device use but avoid shaming. Focus on ensuring device use does not replace all direct social interaction.
Parent-child relationship qualityAutism can make parent-child relationships challenging — reduced reciprocity causes parental pain and potential depressionValidate that love and need are expressed differently by autistic children. NAS Earlybird programme post-diagnosis. CAMHS parenting support if relationship strained.
1D — ICE: Ideas · Concerns · Expectations
💡 Why ICE matters in autism — guilt, labelling, and the grandparents

Parents presenting with autism concerns carry a unique burden: guilt (did I cause this?), fear of "labelling" their child, resistance from extended family, and uncertainty about the future. The ICE conversation must address: what the parents think is causing the difficulties; what they are frightened of; and what they need today. "Wait and see" is not a neutral response — it is harmful, because it delays the diagnosis and the support that comes with it.

💭 Ideas
"What do you think might be causing the differences you are seeing in Ethan — have you had any thoughts or done any reading about it?"
Many parents have already identified autism as a possibility from their own research — naming it gives them permission to discuss it openly. Understanding the parents' model guides the conversation — if they already suspect autism, the discussion is different than if they attribute difficulties to late development.
😟 Concerns
"What is the thing you are most worried about — for Ethan, and for your family? Is it the word autism itself that feels frightening?"
Two dominant fears: (1) "Labelling" — the therapeutic response: a diagnosis enables support, not limitation; without it, school cannot access funding and family cannot access benefits. (2) "What does the future look like?" — accurate, hopeful, individualised prognostic information is the most therapeutic response.
🎯 Expectations
"What were you hoping we would do today — start the referral process, hear my view, or something else?"
Most parents attending with these concerns want a referral and to be taken seriously. Explicitly starting the referral today — even if the waiting list is long — validates the concern, starts the clock on support access, and gives the parents something concrete.
1E — Psychosocial context
😔 Parental Mental Health and Burnout

The period between parental concern and autism diagnosis is often the most psychologically demanding. Parents are managing a child whose needs they do not fully understand, without support, without a diagnosis, and frequently without family validation. PHQ-9 and GAD-7 at this appointment. NHS Talking Therapies/CBT for parental anxiety. Carer's assessment via social services.

"How are you both doing through all of this? This period — before you have any answers — is often the hardest. I want to make sure you are getting support too, not just Ethan."
👴 Extended Family Conflict

The grandparent position ("all boys talk late," "he will grow out of it") is one of the most common barriers to parental help-seeking. The GP has authority to validate parents in a way extended family members lack — "as a doctor, I share your concern and I think referral is the right step" can shift family dynamics.

"I want to say clearly: your concerns are clinically valid and I share them. You are not worrying unnecessarily. The referral I am making today is the right medical step for Ethan."
🏫 School Transition and EHCP Timing

Ethan is 3.5 — school starts in 18 months. The EHCP process takes up to 20 weeks. Starting the diagnostic process now is urgent in the context of school readiness. Delayed diagnosis means delayed EHCP, which means Ethan entering school without the support he needs.

"I want to mention the school timing: Ethan will start school in about 18 months. Getting a diagnosis and the right educational support plan in place before he starts is really important — the sooner we refer, the better."
💰 Financial and Practical Impact

Disability Living Allowance (DLA) for children: payable from diagnosis (or earlier in some cases). DLA can fund respite care, travel, equipment, and activities. Carer's allowance for parents who reduce working hours. Signpost to Citizens Advice, local authority SEND information, and National Autistic Society benefits helpline.

"A diagnosis opens doors to financial support and services. Your local authority SEND team and the National Autistic Society can advise you on what Ethan is entitled to."
🧸 Correcting the Autism Prognosis Fear

Many parents fear autism means their child cannot love, cannot have a fulfilling life, or will need lifelong institutional care. Autism is a spectrum with enormous diversity. Many autistic people live independently, form meaningful relationships, and contribute professionally. The GP can correct these misconceptions with evidence and hope.

"An autism diagnosis does not determine Ethan's future. Many autistic people live independently, have families, and lead fulfilling lives. What it means is that he learns differently — and our job is to make sure the world understands that and supports him."
🎭 Masking in Girls — Later Presentation

Girls are diagnosed on average 4.6 years later than boys. Masking/camouflaging — consciously or unconsciously mimicking social behaviour — allows autistic girls to appear socially competent while experiencing significant internal distress. Girls are often diagnosed after a mental health breakdown in adolescence. Maintain a low threshold for referral in girls presenting with anxiety, eating difficulties, or school refusal.

"Many autistic girls are missed because they copy social behaviours and appear to fit in. If you have a daughter showing similar features, please come back — girls often present differently and are more easily missed."
🎓 SCA Checkpoint — Step 1TasksRelating to OthersGlobal Skills
Key phrases that score
"The things you are describing — Ethan not pointing to share things, not being interested in other children, and his strong need for sameness — these are two specific patterns I want to ensure are assessed by a specialist team."
"I want to be clear: you are not worrying unnecessarily. Your observations are exactly the kind of thing I take seriously. I am going to refer Ethan to the autism assessment team today."
"I am also arranging a hearing test — not because I think that is the cause, but because we always check hearing as part of this assessment."
Deductions
  • "Wait and see" or "he may just be a late talker" — explicitly contradicted by NICE CG128/CG170
  • Not screening Domain B (restricted/repetitive behaviours)
  • Not arranging concurrent audiology
  • Reassuring parents that eye contact means it is not autism
  • Not addressing grandparents' position
🔴 Red
"Wait and see" given; Domain B not screened; hearing not mentioned; grandparents' view reinforced; referral not made; parents dismissed
🟠 Amber
Domain A screened but Domain B not; referral made but audiology not concurrent; grandparents' view not addressed; ICE partial; parental mental health not checked
🟢 Green
Both DSM-5 domains; no "wait and see"; referral + audiology + SALT today; parents validated; grandparents' view addressed sensitively; PHQ-9; school timing; NAS signposted; closing question
2
Step 2
Triage Engine — Emergency · Urgent · Routine
collapse
Most suspected autism presentations are routine referrals — but regression, seizures, and parental crisis may require urgent or same-day action. NICE CG128/CG170: if autism is suspected, refer. The GP does not need to "be sure." The referral pathway varies by area: SPOA (Single Point of Access), community paediatrics, or CAMHS.
🔴 Emergency / Urgent

Same Day to 2 Weeks

Act before diagnostic referral
  • Developmental regression — loss of words or skillsUrgent paediatrics + EEG within 2 weeks. Exclude Rett syndrome, Landau-Kleffner, metabolic conditions. Never manage as "autism variant" without investigation.
  • New-onset seizures in child with developmental concernsUrgent EEG + paediatric neurology. 1-in-3 autistic people develop epilepsy — first seizure requires urgent assessment.
  • Parental mental health crisis — risk to self or childAdult mental health emergency referral. Children's social care MASH referral if child safety at risk.
  • Stereotyped hand movements in girl with regressionPossible Rett syndrome — urgent genetics + paediatric neurology. MECP2 mutation test.
🟠 Urgent

Weeks to 2 Months

Referral + concurrent support
  • Suspected autism — school starting in <12 monthsUrgent autism assessment referral with school-readiness framing; involve school SENCO immediately; EHCP process begins now
  • Significant sleep disorder with parental crisisMelatonin (Slenyto) while awaiting assessment; behavioural sleep programme; parental wellbeing support
  • No words at 24 months / no two-word combinations at 30 monthsUrgent SALT concurrent with paediatric assessment; audiology same week
🟢 Routine

Standard Assessment Pathway

Autism assessment team
  • Suspected autism — both domains present, no urgent featuresNICE CG128/CG170: community paediatrics / CAMHS autism team / SPOA; ADOS-2 and ADI-R; waiting time 12–24 months in most areas
  • Concurrent audiologyFormal hearing assessment regardless of clinical certainty about autism — mandatory baseline
  • SALT referralConcurrent with autism referral — support communication during the waiting period
🎓 SCA Checkpoint — Step 2Tasks
Triage communication
"I am making the autism assessment referral today. I want to be honest — waiting times in most areas are 12–18 months. But starting the referral now is important for Ethan's school support, and there are things we can do in that time that will genuinely help."
Deductions
  • Not referring because "he is too young" — referral can be made from age 2 or earlier if regression
  • Not addressing waiting time honestly — parents need to plan
  • Not initiating concurrent support (audiology, SALT) while waiting
3
Step 3
Do I Need This Examination?
collapse
The GP examination in suspected autism excludes medical causes of developmental difficulties, documents milestones, and identifies comorbid conditions. Autism diagnosis requires specialist MDT assessment — the GP examination informs but does not diagnose.
ExaminationWhy it mattersFinding that changes managementChanges?
Observation of social interaction in consultationDoes the child make eye contact? Explore the room appropriately? Respond to their name? Show social referencing? Spontaneous pointing? These observations inform but do not diagnose.A child who plays well in the consultation does not exclude autism — autistic children may function well in one-to-one structured settings but have difficulties in groups.No response to name, no pointing, no social referencing → supports referral. Normal interaction → does not exclude autism; history remains primary.Context — informative but not diagnostic
Growth — height, weight, head circumference (centile chart)Macrocephaly (above 98th centile) associated with autism (PTEN), hydrocephalus, Sotos syndrome. Faltering growth may indicate feeding difficulties from sensory issues or GI comorbidity.Macrocephaly → genetics referral; PTEN. Faltering growth → dietitian; GI assessment.YES — flags genetic or nutritional comorbidity
Skin inspection (Wood's lamp if tuberous sclerosis suspected)Tuberous sclerosis: ash-leaf hypopigmentation patches (Wood's lamp), angiofibromas, epilepsy, autism. Neurofibromatosis: café-au-lait patches.Ash-leaf patches → tuberous sclerosis; urgent MRI brain + renal + ophthalmology + genetics. Café-au-lait spots → NF1 assessment.YES — identifies genetic syndrome
Neurological examination — tone, reflexes, coordination, gaitHypotonia in Down syndrome, Angelman, metabolic conditions. Focal signs warrant urgent MRI. Rett syndrome: progressive loss of hand use, hyperventilation, autonomic dysfunction.Hypotonia → metabolic and genetic screen. Focal signs → urgent MRI. Normal → does not exclude autism.Context — triggers specialist workup if abnormal
Dysmorphic featuresFragile X (large ears, long face, macroorchidism in males), Down syndrome, Williams syndrome, Angelman, 22q11 deletion — all associated with autism-like features and intellectual disability.Dysmorphic features → genetics referral; chromosomal microarray. No dysmorphic features → idiopathic autism most likely.Context — genetics referral if dysmorphic
Ear examination + audiology (formal)GP otoscopy insufficient to exclude hearing loss. OME (glue ear) at 3–5 years causes fluctuating hearing loss mimicking or compounding autism. Formal audiology (behavioural audiometry, OAEs, tympanometry) is mandatory.Hearing loss → treat concurrently; ENT for persistent OME. Normal hearing → autism-specific features more likely.YES — mandatory concurrent with referral
🎓 SCA Checkpoint — Step 3Tasks
Examination rationale
"I am going to look at Ethan today — check his growth, look at his skin, and observe how he interacts. I am not diagnosing autism through this — that requires a specialist team. I am looking for anything that needs urgent attention before the assessment team sees him."
Deductions
  • Diagnosing or excluding autism based on GP examination
  • Reassuring parents because the child behaved well in the consultation room
  • Not checking growth parameters (missed genetic syndromes)
4
Step 4
Do I Need This Investigation?
collapse
NICE CG128/CG170: routine blood tests and imaging are not required for autism diagnosis. Investigations are indicated when specific clinical features suggest a genetic, metabolic, or neurological cause. The specialist MDT assessment (ADOS-2, ADI-R) is the primary diagnostic pathway.
InvestigationWhen indicatedResult that changes management
Formal audiology (behavioural audiometry, OAEs, tympanometry)Mandatory for ALL children with developmental language delay or communication concerns — concurrent with autism referral. GP otoscopy does not suffice.Hearing loss → treat (ENT, grommets, hearing aids) and reassess language. Normal → autism assessment proceeds without confound.
Chromosomal microarray (via genetics — dysmorphic features or ID)Not routine. Indicated when dysmorphic features, intellectual disability, or specific genetic syndrome suspected. Fragile X testing (CGG repeat): boys with autism + ID + large ears/macroorchidism.Genetic variant → syndrome-specific monitoring and genetic counselling. Normal → idiopathic autism; does not change autism management.
EEG (if seizures or developmental regression)Indicated: new onset seizures; developmental regression (exclude Landau-Kleffner syndrome); clinical suspicion of epileptic encephalopathy. NOT routine for all autistic children.Epileptiform activity → paediatric neurology; anti-epileptic therapy. Landau-Kleffner → corticosteroids/clobazam. Normal EEG in regression → serial EEG may be needed.
Metabolic screen (if intellectual disability or regression)Indicated when: significant ID without genetic explanation; developmental regression; clinical features suggesting metabolic disorder. PKU detected on Guthrie screen but IEMs can be missed.Metabolic disorder → specific treatment. Normal → idiopathic autism or genetic cause.
Lead level (if pica — eating non-food items)Pica in autistic children with sensory seeking. Lead poisoning from paint can cause or worsen neurodevelopmental difficulties.Elevated lead → remove from source; health protection notification; chelation if severe. Normal → pica management (supervision, sensory alternatives).
MRI brain (focal signs, macrocephaly, regression, tuberous sclerosis)NOT routine for autism. Indicated: focal neurological signs; macrocephaly; tuberous sclerosis suspected; regression without EEG explanation.Tubers → tuberous sclerosis confirmed; epilepsy monitoring. Structural lesion → neurosurgical assessment. Normal → supportive of idiopathic autism.
🎓 SCA Checkpoint — Step 4Tasks
Investigation rationale
"I am going to arrange a formal hearing test as part of this assessment. I am not ordering blood tests or a brain scan at this stage — the guidelines say these are not helpful for diagnosing autism unless there is a specific medical reason."
Deductions
  • Not arranging concurrent audiology — mandatory
  • Ordering MRI brain or blood tests routinely — not per NICE CG128/CG170
  • Not ordering EEG when regression is present
5
Step 5
Reaching a Diagnosis & DDx — Explained in Plain Language
collapse
Autism is diagnosed by the specialist MDT — the GP explains the clinical picture, corrects misunderstandings, and addresses the fear of the diagnosis.
🗣️ Explaining the Autism Pattern in Plain Language

"Autism is a different way of experiencing and processing the world — not a disease, not a failure of parenting, and not something that happened to Ethan. His brain processes social information, sensory experiences, and change differently from most people. This makes some things harder — reading social cues, tolerating uncertainty, unexpected change. And often, some things easier or more intense — concentrating deeply on things he loves. It is lifelong, but it changes with age and with the right support. With early intervention, many autistic children develop skills that allow them to navigate the world on their own terms. What matters now is getting him the right assessment and the right support as early as possible."

💬 Addressing common parental misconceptions

"We caused this — screens, our parenting, something we did."
"Autism is not caused by parenting, screens, vaccines, or diet. It has a strong genetic basis and is present from birth. You did nothing to cause this. What you are doing right now — coming here, advocating for Ethan — is what good parenting looks like."

"If we give him a diagnosis, he will be labelled and held back for life."
"A diagnosis does not create limitations — it removes them. Without a diagnosis, the school cannot access the support funding he needs, he cannot get an EHCP, and you cannot claim DLA or access many services. The diagnosis is the key that unlocks support — not a ceiling on his potential."

A — Autism Spectrum Disorder (DSM-5)
Specialist MDT diagnosis
Domain A — Social Communication Deficits
Social-emotional reciprocity; non-verbal communicative behaviours (pointing, eye contact, gestures); developing/maintaining/understanding relationships. Must be present across multiple contexts.
Domain B — Restricted/Repetitive Behaviours (≥2)
Stereotyped motor movements; insistence on sameness/inflexibility; highly restricted/fixated interests; hyper- or hypo-sensitivity to sensory input. Both domains required. Present from early developmental period.
B — Differential Diagnoses
Specialist assessment required

Hearing Impairment

Mimics autism — language delay, poor social response. Audiology mandatory before autism assessment. Can co-occur.

Developmental Language Disorder (DLD)

Language delay without autism social features. Social communication qualitatively intact; no Domain B. SALT assessment.

ADHD / Social Pragmatic Communication Disorder

Social difficulties from inattention rather than social motivation differences. Domain A features without Domain B. CAMHS assessment.

C — Urgent Medical Investigations
Act before autism assessment

Rett Syndrome (Girls)

Normal development to 6–18 months, then regression, hand-wringing, breathing irregularities. MECP2 mutation. Urgent genetics + neurology. Distinct from autism.

Tuberous Sclerosis

Ash-leaf patches + epilepsy + autism. MRI brain + renal surveillance + genetics. Targeted management independent of autism diagnosis.

🎓 SCA Checkpoint — Step 5TasksRelating to Others
Explaining the pattern
"I am not diagnosing Ethan today — that is what the specialist team does with specific tools over several sessions. What I can tell you is that the pattern you are describing — the pointing, the routines, the different social engagement — fits with what I would expect to see in a child who might be autistic. The referral I am making today is exactly the right step to find out."
Deductions
  • Diagnosing autism in the GP consultation
  • Excluding autism because child seems sociable or verbal
  • Not addressing the "labelling" concern
6
Step 6
If Referral Is Needed — What the GP Does Before & During
collapse
NICE CG128/CG170 is unambiguous: if autism is suspected, refer. Do not wait for hearing results before referring — arrange audiology concurrently. The referral letter should document both DSM-5 domains, milestones, hearing status, family history, and parental concerns.
ReferralUrgencyWhat to includeWhat NOT to do
Autism assessment service (NICE CG128/CG170)Routine — SPOA/community paeds/CAMHSBoth DSM-5 domains documented; no pointing, insistence on sameness; hearing status; developmental milestones; family history; school/nursery observations; parental concern.Do NOT defer pending hearing results. Do NOT "wait and see." Do NOT decline because child has eye contact or is verbal.
Audiology (formal)Concurrent — within 4 weeksBehavioural audiometry + OAEs + tympanometry. Child has language delay/communication concerns. Full audiological report.Do NOT accept "neonatal hearing screen was normal" as sufficient.
SALT (concurrent)RoutineLanguage delay + social communication concerns. Autism assessment also in progress. SALT supports communication during the waiting period.Do NOT wait for autism diagnosis before starting SALT.
Paediatric neurology (developmental regression + seizures)Urgent — 1–2 weeksRegression timeline; age of onset; rate of change; skills lost. EEG arranged concurrently. Rett syndrome features if present.Do NOT manage developmental regression as "autism variant" without EEG.
School SENCO engagementImmediateAdvise parents to contact SENCO immediately. SEND Support Plan can begin before diagnosis. SENCO observations contribute to assessment. EHCP application starts now.Do NOT tell parents to wait for diagnosis before approaching school — EHCP takes 20 weeks and support can begin before diagnosis.
📋 Model Referral Letter — NICE CG128/CG170-Compliant
Dear Autism Assessment Team, I am referring Ethan Fletcher (DOB [date]) aged 3 years 6 months for autism assessment. Parental concerns: (1) Domain A — absent proto-declarative pointing, reduced peer interest, limited social reciprocity; (2) Domain B — insistence on sameness (fixed routes, identical routines), restricted interests (lining objects), sensory sensitivities. Language: 10–15 single words, not combining, echolalia. No regression. Hearing test: audiology referral arranged concurrently. Family history: none known. No dysmorphic features. Nursery SENCO observations requested. Please let me know if further information is required. I support the application for an EHCP to commence before school entry.
🎓 SCA Checkpoint — Step 6Tasks
Referral explained
"I am making three referrals today: autism assessment, audiology, and speech therapy. These happen simultaneously — you do not wait for one before the others start."
Deductions
  • Single referral without concurrent audiology and SALT
  • Waiting for hearing results before autism referral
  • Not advising parents to contact school SENCO now
7
Step 7
Management — Expectation · Goals · Lifestyle · Medications · Psychosocial · Follow-Up · Safety-Netting
collapse
7A — Address expectations: validate the parents, explain the wait honestly, and plan for the waiting period
🤝
The waiting period is not empty — it is an active period of support gathering, school preparation, and family wellbeing
1
Validate — their knowledge is the data

Parents of autistic children are the primary historians and often the most accurate observers of their child's behaviour. Explicitly naming their expertise counters the dismissal they have likely experienced from extended family and possibly previous consultations.

"Everything you have described — the pointing, the routines, the way Ethan plays — these are exactly the kind of observations that matter most. You are not overreacting. You are right to be here."
2
Explain — honest waiting time

The waiting time for formal autism assessment in most areas is 12–24 months. Parents who are not told this feel abandoned and do not understand why nothing appears to be happening after the referral is made. Honesty about the timeline, combined with concrete interim actions, is far more therapeutic than false reassurance.

"I want to be honest with you — in most areas the waiting time for the full assessment is 12–18 months. That is too long, and I am sorry. But starting the referral today is still the right step, and there are concrete things we can do right now that will genuinely help Ethan."
3
Plan — what happens today

Today: autism referral sent; audiology arranged; SALT arranged; NAS website given; school SENCO advice; sleep discussed. These are all actionable before the assessment appointment. The GP should be named as the person who coordinates this interim period.

"I am making three referrals today. While you wait, the National Autistic Society website has excellent resources for families at exactly this stage. And if sleep is disrupted — which you mentioned — that is something we can start to help with now."
Key principle: The GP is the named coordinator of the waiting period. Concurrent referrals (autism assessment, audiology, SALT, school SENCO), interim comorbidity management (sleep, GI, anxiety), and family wellbeing support (parental PHQ-9, NAS signposting, DLA advice) should all begin today — not after the diagnosis arrives.
7B — Management goals
Management goals
Autism assessment referral made todayAudiology and SALT concurrent referrals Sleep addressed — Slenyto if significant disruptionEHCP application before school entry at age 5 Parental PHQ-9; NHS Talking Therapies if indicated; NAS resourcesSchool SENCO engaged; SEND Support Plan commenced DLA application information provided today6–8-week follow-up: referral progress + family wellbeing
Key messages for today
"There is no medication for autism itself — but there are very effective ways to support Ethan's specific challenges. Sleep is the most impactful thing we can address now: if his sleep improves, his behaviour, learning, and your family's wellbeing will all improve too."
"An autism diagnosis does not determine Ethan's future. Many autistic people live independently, have families, and lead fulfilling lives. What it does mean is that he learns differently — and our job is to make sure the world understands that and supports him accordingly."
7C — Evidence-based non-medication interventions
No pharmacological treatment targets core autism features. NICE CG128/CG170 recommends: parent-mediated social communication intervention; SALT with social communication focus; OT for sensory processing; educational support via EHCP. All should begin during the waiting period, not after diagnosis.
🗣️
Speech & Language Therapy
Concurrent referral — not after diagnosis
Evidence

SALT focused on social communication (not just vocabulary): PECS, Makaton, Social Stories, AAC devices for non-verbal children. Early SALT intervention improves communication outcomes regardless of whether autism is the eventual diagnosis.

Practical

NHS SALT; school SALT; independent SALT if waiting too long. Visual schedules can be implemented by parents at home without formal therapy, using PECS format. NAS communication guides available free online.

Core NICE CG128/CG170 recommendation — start now
👪
Parent-Mediated Intervention
PACT; NAS Earlybird post-diagnosis
Evidence

PACT trial (Preschool Autism Communication Trial): RCT with sustained gains at 13-year follow-up. NAS Earlybird: 12-week post-diagnosis programme for families of young autistic children. Training parents to use responsive interaction strategies is immediately implementable.

Practical

GP can signpost NAS resources before diagnosis. Local Early Support programmes (varies by CCG). NAS Earlybird post-diagnosis. CAMHS parenting support if relationship significantly strained.

RCT evidence: sustained gains at 13 years
🔧
Occupational Therapy — Sensory
Sensory profile + sensory diet
Evidence

OT with sensory integration specialisation creates a sensory profile and diet tailored to the child. Sensory overload (fluorescent lighting, background noise, physical contact) drives meltdowns — understanding and reducing sensory triggers is one of the most practically impactful early interventions.

Practical

Community paediatrics / CAMHS OT referral. OT report shared with school enables adaptations: ear defenders, fidget tools, calm space access, reduced transition noise. Sensory diet implemented simultaneously at home and school.

Reduces meltdown frequency when sensory triggers identified
🏫
EHCP and Educational Support
Application before school entry at age 5
Evidence

EHCP (Education, Health and Care Plan): legally binding document specifying required school support. Application can be made before diagnosis. Process takes up to 20 weeks. Schools must make reasonable adjustments even without EHCP under the Equality Act 2010.

Practical

Parents apply to local authority. SENDIASS support. School SENCO involvement from the outset. GP supporting letter significantly strengthens the EHCP application. Target: EHCP in place before Ethan starts school at age 5.

Legally mandated — every autistic child is entitled
😴
Sleep Hygiene Programme
Consistent bedtime routine; behavioural first
Evidence

80% of autistic children have sleep difficulties. Behavioural sleep programme first: consistent visual bedtime schedule; dark/quiet environment; reduced sensory stimulation 1h before bed; gradual withdrawal of parental presence at sleep onset. Sleep improvement has the largest downstream effect on daytime behaviour.

Practical

Visual bedtime schedule in PECS format helps transition predictability. Sleep diary for 2 weeks. Weighted blankets may help sensory regulation. Melatonin (Slenyto) after 3 months of inadequate behavioural response. CAMHS sleep clinic if complex.

Sleep improvement has the largest effect on daytime behaviour
💚
Parental and Family Wellbeing
PHQ-9 + carer's assessment
Evidence

Parental mental health directly impacts child outcomes. PHQ-9 and GAD-7 at every GP appointment. NHS Talking Therapies/CBT for parental anxiety and depression. Carer's assessment (legal entitlement) through social services unlocks respite care, financial support, and community support.

Practical

NAS helpline: 0808 800 4104. National Parent Carer Forum. DLA application. Short Breaks (respite care). Remember neurotypical siblings — they may have unmet needs that are overlooked.

Parent wellbeing is part of child safeguarding — not an optional extra
7D — Prescribing guide: comorbidities only — no medication for core autism features
NICE CG128/CG170 is explicit: there are no medications for core autism features. Medications address specific comorbidities: sleep disturbance (melatonin — first-line, licensed), ADHD (methylphenidate or atomoxetine — specialist initiation), anxiety (autism-adapted CBT first; SSRIs with specialist guidance only), and challenging behaviour (antipsychotics — specialist initiation only, never in primary care, not for core autism). GI comorbidity (constipation — extremely common; treat before attributing behaviour change to autism).
Sleep — Melatonin (Slenyto) — licensed, no NICE TA

Slenyto (melatonin prolonged-release) 1–5mg ON, 30–60 min before bedtime. Licensed age 2–18 for autism sleep disorders.

  • NICE BNFc (2021): melatonin PR licensed specifically for sleep disorders in autism in children aged 2–18
  • Indicated after ≥3 months of behavioural sleep programme without adequate response
  • Titrate from 1mg to 5mg based on response; give 30–60 min before desired sleep onset
  • Can be prescribed by GP after specialist recommendation
Slenyto is the licensed formulation for autism. Unlicensed liquid melatonin also used in practice. Always trial sleep hygiene programme first. Annual review of continued need.
ADHD Comorbidity — Specialist Initiation

Methylphenidate or Atomoxetine — after specialist ADHD assessment

  • 50–70% of autistic children have ADHD features — NICE NG87 pathway applies
  • Methylphenidate may be less effective and more likely to worsen anxiety or stereotypies in autistic children — atomoxetine or guanfacine preferred if anxiety is prominent (specialist decision)
  • Height and weight every 6 months on centile chart — mandatory monitoring for all stimulants
GI Comorbidity — Treat Before Attributing Behaviour

Movicol Paediatric — for constipation (up to 50% of autistic children)

  • Constipation in autism: multifactorial (dietary restriction, low fibre, sensory issues with toileting, medication side effects)
  • Behaviour change in a non-verbal autistic child = investigate physical pain first. Constipation, ear infection, toothache, and GERD can all present as increased aggression or distress
  • Movicol paediatric plain: 1 sachet per year of age per day as initial dose
Anxiety Comorbidity — CBT First; SSRIs with Caution
  • Anxiety is the most common comorbid mental health condition in autistic children (up to 50%)
  • Autism-adapted CBT is first-line per NICE CG128/CG170 — specifically adapted to account for autistic social communication and cognitive style
  • SSRIs (sertraline — off-label; start at 25mg OD, lower than standard): limited evidence in autism; higher risk of behavioural activation (agitation, increased stereotypies, self-injury) than in non-autistic children. Specialist recommendation first.
Antipsychotics — SPECIALIST ONLY; Not for Core Autism
  • NICE CG128/CG170: do NOT use antipsychotics for core autism features — only for challenging behaviour causing serious harm, after all behavioural interventions exhausted, with specialist oversight
  • Aripiprazole / risperidone: significant metabolic monitoring required (weight, glucose, lipids, AIMS scale)
  • NEVER initiate antipsychotics in primary care for an autistic child without explicit specialist recommendation and monitoring plan
7E — Medication selector

Select the comorbidity — see drug cards below for full guidance

Comorbidity management guide
Sleep: Slenyto 1–5mg ON (licensed for autism sleep age 2–18; BNFc — no NICE TA) after 3-month sleep hygiene trial. ADHD: Methylphenidate (with caution — may worsen anxiety/stereotypies in autism) or Atomoxetine (preferred if anxiety prominent) — specialist initiation only. Anxiety: Autism-adapted CBT first-line; SSRIs only with specialist recommendation (behavioural activation risk higher in autism). Challenging behaviour: Aripiprazole/Risperidone — NEVER GP-initiated; specialist only; not for core autism. GI/Constipation: Movicol paediatric (behaviour change = check pain first). Epilepsy: Urgent EEG + paediatric neurology; AED specialist. NO medications for core autism features.
7F — Drug reference cards: autism comorbidity management
Melatonin PR (Slenyto) — Sleep in Autism
Slenyto 1mg / 5mg prolonged-release tablets · Licensed: autism sleep age 2–18 · NICE BNFc
✓ First-line for sleep
NICE BNFc licensed1mg ON → 5mg; 30–60 min before bed
✓ Prefer when
Sleep onset delay (>60 min to fall asleep) in autism — after ≥3 months of behavioural sleep programme without adequate response
NICE BNFc: the only licensed paediatric melatonin for autism sleep — Slenyto is specifically approved for sleep disorders in autism age 2–18
Prolonged-release formulation covers early-morning waking pattern common in autism (superior to immediate-release for this reason)
✗ Cautions
Behavioural sleep programme must be tried first — melatonin works alongside routine, not instead of it; prescribing without a behavioural programme is suboptimal
Other causes of sleep disruption (pain, GI, anxiety, ADHD) should be identified and treated concurrently — melatonin alone will not work if physical pain is disrupting sleep
⚠ Side effects
Generally very well tolerated. Daytime drowsiness if dose too high. Headache. Enuresis (rare). Morning grogginess can occur with 5mg — may need to reduce.
🔬 Monitor
Sleep diary at 2 weeks and 6 weeks. Review dose every 6 months. Annual cessation trial — many children can eventually stop. If no response after 4 weeks at 5mg: specialist CAMHS sleep review.
💬 Counselling

"Give this tablet 30 minutes before the bedtime routine ends. The routine itself is just as important — the tablet helps the brain's natural sleep signal work at the right time. Keep the room dark and calm after giving the tablet."

Slenyto is the MHRA-licensed melatonin (no NICE TA; NICE CG170 says consider melatonin after a sleep programme) for autism sleep in children aged 2–18. Always after a behavioural sleep programme trial. There is NO medication for core autism features — melatonin targets only the sleep comorbidity. Annual review of continued need.

Methylphenidate — ADHD Comorbidity in Autism
Concerta XL 18–54mg OD · Ritalin LA 10–40mg OD · Schedule 2 controlled drug
✓ Specialist-initiated
ADHD comorbidity — specialist initiatesStart low; slower titration than non-autistic ADHD
✓ When to use
ADHD features confirmed by specialist assessment — comorbidity present in 50–70% of autistic children; NICE NG87 pathway applies; Schedule 2 CD; monthly prescriptions; specialist initiation essential
✗ Cautions specific to autism
Lower efficacy in autism (~50% response vs 70% in non-autistic ADHD). May worsen anxiety, stereotypies, or irritability in autistic children — monitor closely and report to specialist if behaviours worsen
If anxiety prominent or tics present: atomoxetine or guanfacine preferred (specialist decision)
⚠ Side effects
Appetite suppression (breakfast before dose), sleep difficulty (early morning administration), increased anxiety or stereotypies in autistic children — amplified risk vs non-autistic ADHD
🔬 Monitor
Height and weight every 6 months on centile chart (mandatory). BP and HR at each prescription. Tics. Anxiety and autism-specific behaviour changes. Report deterioration in autism-related behaviours to specialist immediately.
💬 Counselling

"This tablet helps with concentration and impulse control — not the autism itself. Give it in the morning with breakfast. Appetite may be lower at lunchtime. If he becomes more anxious, more agitated, or his movements change, please contact us."

Methylphenidate in autism: lower efficacy; higher worsening-anxiety risk. Atomoxetine or guanfacine preferred if anxiety prominent. Growth monitoring every 6 months mandatory. Monthly CD prescriptions — cannot write >28 days. Specialist initiates; GP on shared care.

Atomoxetine — ADHD + Autism (Non-Stimulant)
Strattera 10–100mg OD or BD capsules · Not a controlled drug
✓ Preferred if anxiety
ADHD comorbidity; preferred if anxiety/tics0.5mg/kg/day → 1.2mg/kg/day
✓ Prefer when
ADHD + autism + comorbid anxiety — atomoxetine does not worsen anxiety (may modestly improve it) unlike stimulants
Tic disorder — non-stimulant preferred; methylphenidate may worsen tics
Previous stimulant trial worsened anxiety, stereotypies, or irritability in autistic child
✗ Absolute contraindications
MAOI within 14 days; narrow-angle glaucoma; phaeochromocytoma; severe hepatic failure
⚠ Side effects
Reduced appetite; nausea (give with food); initial insomnia; mood changes. Black-box warning: suicidal ideation in children and adolescents — monitor at 1, 2, 4, 8, 12 weeks after starting or dose change.
🔬 Monitor
BP and HR. Growth centile chart. PHQ monitoring for mood. Takes 4–6 weeks for full effect — warn parents explicitly; many stop early thinking it has not worked. CAMHS oversight mandatory.
💬 Counselling

"This is a non-stimulant ADHD medication — it works differently from the other type. There is no on-off effect. It takes 4–6 weeks to work, so please give it that time. Take with food. Tell us immediately if his mood changes or if you are worried about him."

Atomoxetine preferred over methylphenidate in autistic children with comorbid anxiety or tics. Takes 4–6 weeks — warn parents not to judge it too early. Black-box: suicidal ideation monitoring in first 12 weeks. Licensed age 6+.

Sertraline — Anxiety in Autism (Specialist Guidance)
Sertraline 25mg / 50mg tablets · Off-label in children; limited evidence in autism
⚠ Specialist recommendation first
Anxiety after CBT failure — specialist only25mg OD start (lower than standard); titrate slowly
✓ When appropriate
Significant anxiety or OCD in autistic child when autism-adapted CBT has been insufficient — specialist confirmation required before GP prescribes
Autism-adapted CBT is first-line per NICE CG128/CG170 — SSRIs are adjunctive, never first-line replacement
✗ Critical caution in autism
Behavioural activation risk is significantly higher in autistic children than in non-autistic children — agitation, impulsivity, increased stereotypies, self-injurious behaviour can be precipitated; start at 25mg OD (not 50mg); titrate very slowly; specific specialist monitoring required
NEVER initiate SSRIs in primary care for autistic children without specialist recommendation and monitoring plan
⚠ Side effects
Behavioural activation (agitation, impulsivity, self-injury — more common in autism). Nausea. Suicidal ideation (black-box warning). Initial anxiety increase before improvement (warn family).
🔬 Monitor
Behaviour diary at 2 and 4 weeks. Black-box: suicidal ideation monitoring. Specifically monitor for behavioural activation in the first 4 weeks. CAMHS oversight mandatory throughout.
💬 Counselling

"This tablet may help with the anxious behaviours, but it can sometimes make children more unsettled before it helps. Please tell us immediately if Ethan becomes more agitated, if there is any self-harming, or if you are worried about him."

SSRIs in autism: limited evidence; higher behavioural activation risk than in non-autistic children. Autism-adapted CBT must be tried first. Never initiate in primary care without specialist recommendation. Start low (25mg), titrate slowly.

Aripiprazole — Challenging Behaviour (SPECIALIST ONLY)
Abilify 2mg / 5mg / 10mg · Not for core autism · Never GP-initiated
⚠ Specialist initiation only
Challenging behaviour — never GP-initiatedSpecialist-determined; comprehensive monitoring plan required
⚠ Absolute prescribing rules
NICE CG128/CG170: do NOT use antipsychotics for core autism features — only for challenging behaviour causing serious harm, after ALL behavioural interventions exhausted, with specialist oversight and metabolic monitoring plan agreed
Never GP-initiated — CAMHS psychiatrist or paediatrician must initiate with specific documented indication and risk-benefit discussion with parents
Significant risks that require monitoring: weight gain, metabolic syndrome, tardive dyskinesia, EPS, raised prolactin — GP shared care monitoring plan mandatory
⚠ Metabolic monitoring (GP shared care)
Weight and BMI monthly × 3 months, then quarterly. Fasting glucose and lipids: baseline, 3 months, then annually. AIMS scale for dyskinesia at each GP review. Any dyskinetic movements → stop and contact specialist urgently.
🔬 GP shared care
Weight at every appointment. Annual fasting metabolic bloods. AIMS scale. Report any motor changes immediately. Annual specialist review with metabolic panel. Ensure shared care agreement is in place before prescribing.
💬 Counselling

"This medication has been prescribed specifically by the specialist to reduce [specific harmful behaviour]. It is not treating autism itself. We will be monitoring weight and blood tests carefully, as this type of medication can cause weight gain."

Absolute SCA rule: never initiate antipsychotics for autism in primary care. NICE CG128/CG170 prohibits antipsychotics for core autism features. Justified only for specific harmful challenging behaviour unresponsive to comprehensive behavioural intervention — specialist only. GP shares monitoring responsibility but never initiates.

Movicol Paediatric — GI Comorbidity in Autism
Movicol Paediatric Plain (macrogol) · Lactulose · Senna
✓ First-line GI management
First-line for constipation1 sachet per year of age per day
✓ When to use
Constipation — present in up to 50% of autistic children; multifactorial: dietary restriction (limited food repertoire), low fluid intake, sensory issues with toileting, reduced physical activity, medication side effects
Behaviour change in a non-verbal autistic child: investigate physical pain first. Constipation, ear infection, toothache, GERD, and urinary tract infection can all present as increased aggression, self-injury, or distress in a child who cannot verbalise pain
✗ Avoid if
Bowel obstruction; suspected serious GI pathology — investigate before laxatives
⚠ Clinical point — abdominal X-ray
Suspected severe faecal loading in a non-verbal autistic child: abdominal plain X-ray to assess loading before or alongside laxative treatment. Behaviour ABC chart: do challenging behaviours cluster around mealtimes and toilet times?
🔬 Monitor
Stool diary (parent/school). Abdominal examination at every review. Dietary review — referral to paediatric dietitian for children with very restricted food repertoire. Review laxative dose monthly until established.
💬 Counselling

"Tummy problems are very common in children with autism — partly because of what they eat, partly because of how their gut works. This treatment makes stools softer and easier to pass. If Ethan has been more distressed or difficult recently, it is worth seeing whether treating constipation helps — sometimes behaviour that looks like autism is actually pain."

Behaviour change in non-verbal autistic children = investigate physical pain first. Constipation is massively underdiagnosed in autism. Treating constipation can dramatically improve behaviour, sleep, and mood without any psychiatric medication. High-impact, low-risk intervention that is often missed.

7G — Psychosocial impact on the family
🫂
Autism — the family condition: parents, siblings, and the weight of the waiting period
An autism diagnosis affects not one person but an entire family system. Parents restructure their working lives, their social relationships, and their sense of identity around their child's needs. Siblings adapt to a household where one child's needs can consume disproportionate parental attention. Extended family members struggle to understand a condition that presents differently in every child. The GP who treats only the autistic child is treating less than half the clinical problem.
😔
Parental Grief and Acceptance

Many parents experience grief after receiving an autism diagnosis or strongly suspecting one — not for the loss of their child, but for a version of the future they had imagined. This grief is valid, normal, and temporary for most parents. It must not be pathologised — but it should be acknowledged.

The transition from grief to advocacy is the most important journey primary care can facilitate. The NAS Earlybird programme, peer support from other autism families, and CAMHS parenting programmes all help this transition.

"How are you both feeling about all of this? It is completely normal to feel very mixed emotions — relief that someone is taking this seriously, grief about what it might mean, and worry about the future, all at once. Those feelings are valid."
👧
Siblings — the Forgotten Children

Neurotypical siblings of autistic children often receive less parental attention, develop anxiety about the family situation, and may have their own unmet neurodevelopmental needs that go unnoticed. They sometimes present to the GP with somatic symptoms (headaches, abdominal pain) or school avoidance that represents unexpressed anxiety about home.

Ask specifically about siblings at every consultation. The Sibs organisation (sibs.org.uk) provides specific support for brothers and sisters of disabled children.

"How are Ethan's siblings doing? Sometimes when one child has significant needs, the other children's feelings can get a bit lost. I want to make sure they are doing well too."
💑
Relationship Strain

Caring for an autistic child significantly strains couple relationships. Sleep deprivation, financial stress, different coping styles, reduced social life, and the intensity of caring responsibilities all contribute. Research shows higher rates of relationship breakdown in parents of autistic children. Relationship counselling (Relate) should be offered proactively — not only after a crisis.

"How are you both supporting each other through this? These situations put a lot of pressure on a relationship — not because you are doing anything wrong, but because it is genuinely hard. There is relationship support available if it would be helpful."
💰
Financial and Employment Impact

One parent frequently reduces working hours or leaves employment to care for an autistic child. Disability Living Allowance (DLA): applicable from diagnosis (sometimes before). Carer's Allowance. Universal Credit adjustments. Short Breaks (respite care). Citizens Advice benefits check. All of these represent legally entitled support that many families do not claim because they do not know about it.

"I want to make sure you know about the financial support Ethan and your family are entitled to. Disability Living Allowance can be applied for now, even before the diagnosis — and there is Carer's Allowance for the parent who reduces work to care for him."
🌍
Cultural Context and Diagnostic Barriers

In some cultural communities, autism may be attributed to spiritual causes, parenting failures, or dietary factors. Stigma around disability can be profound. Grandparents and extended family may actively oppose the diagnostic process. The GP can be the authoritative professional who validates the parents' concerns in the face of family pressure — "as a doctor, I share your concern and I am making this referral today" has real clinical weight.

"I understand your family may see this differently — different families have different frameworks for understanding these things. My role is to make sure Ethan gets the right assessment, and I want to work with you in a way that makes sense for your whole family."
🔮
Prognosis and Future Planning

Autism is lifelong. Many autistic adults live independently, work in a variety of professions, maintain relationships, and describe their autism as an important part of their identity rather than a disease. Approximately 30–40% of autistic adults are in paid employment. Intellectual disability significantly affects outcomes. Early diagnosis and early intervention are the two most modifiable factors associated with better outcomes. Transition planning from childhood to adult services begins at age 14 — much earlier than many families expect.

"I know the future feels very uncertain right now. What I can tell you is that autism is a lifelong difference, but it changes enormously with age and with the right support. Many autistic adults lead very fulfilling independent lives. The most important thing right now is getting the assessment and support in place as early as possible — and that is exactly what we are doing today."
7H — Follow-up schedule
1
6–8 Weeks — Referral Progress + Sleep + Parental Wellbeing

Referral acknowledged? Audiology appointment received? SALT underway? Sleep: has behavioural programme been started — is melatonin now needed? Parental PHQ-9. School SENCO engaged? SEND Support Plan in place? Any new concerns (regression, seizures, behaviour change)? DLA application started? Any deterioration in Ethan's or parents' wellbeing?

Referral progress checkSleep + PHQ-9
2
3–6 Months — Active Waiting Period Review

SEND Support Plan in place at nursery? EHCP application progressing? Sleep: melatonin effective? ADHD assessment needed? Behaviour: any escalation requiring CAMHS? Parental mental health. New medical concerns (seizures, regression). Family support services accessed (Short Breaks, carer's assessment)? Dietitian if restricted food repertoire.

EHCP progressCAMHS if behaviour escalating
3
Post-Diagnosis — Navigation and Service Access

Diagnosis received? NAS Earlybird referral immediately. DLA applied for. EHCP application if not yet started. Comorbidity assessments: ADHD, anxiety — are these now apparent? Parental wellbeing. Genetic counselling if genetic syndrome identified. Epilepsy surveillance plan. Annual GP review agreed.

Diagnosis → unlock servicesNAS Earlybird; DLA; EHCP
4
Annual Review

Growth and nutrition (food restriction common in autism; faltering growth warrants dietitian). Sleep (melatonin review; annual cessation trial). Comorbidities (ADHD, anxiety, epilepsy — 1-in-3 develop epilepsy; new staring episodes, absences, or unusual movements = EEG urgently). Medication review (melatonin, stimulants). School situation. EHCP annual review. Parental wellbeing. Sibling wellbeing. Transition planning begins age 14.

Annual medication reviewGrowth + epilepsy surveillance
5
Any-Time Presentations

Behaviour change in non-verbal child → investigate physical pain first (constipation, GERD, ear infection, dental pain) before attributing to autism. New seizures → urgent paediatric neurology. Regression → urgent paediatric assessment + EEG. Safeguarding concern → MASH referral. Parental crisis → same-day adult mental health. School exclusion → advocate immediately.

Behaviour change → physical pain firstNew seizures → urgent
7I — Monitoring: comorbidity surveillance and medication safety

Annual autism review in primary care — memory framework

At every autism review check: growth (weight + height centile chart — food restriction common); sleep (melatonin dose review; annual cessation trial); GI (constipation — active screening, not passive); epilepsy (1-in-3 develop epilepsy; new staring spells, absences, unusual movements = EEG); ADHD (medication review; growth monitoring); mental health (anxiety, depression, OCD — more common than in neurotypical peers); family wellbeing (parental PHQ-9; carer's assessment); transition planning (begin age 14 — much earlier than most families expect).

Medication / targetMonitorTimingAction threshold
Melatonin (Slenyto)Sleep diary; daytime drowsiness6 weeks; then 6 monthlyNo response at 5mg → CAMHS sleep review; consider behavioural programme intensification. Annual cessation trial — many children can eventually stop as circadian rhythm matures.
Methylphenidate / AtomoxetineHeight + weight centile chart; BP; HR; tics; anxiety; appetiteMonthly × 3; then 6 monthlyHeight velocity crossing centile → review dose; consider drug holiday. New tics → specialist review. Worsening anxiety or stereotypies → specialist urgently.
Aripiprazole / Risperidone (specialist-initiated)Weight + BMI; fasting glucose + lipids; AIMS scaleMonthly × 3; quarterly thereafterBMI gain >2 points → specialist review. Dyskinesia on AIMS → specialist review (dose reduction / cessation). Annual metabolic panel.
Epilepsy surveillance (all autistic children)Parent report of seizure-like episodes; annual GP reviewAnnualAny new staring spells, absences, convulsions, or unexplained falls → urgent EEG + paediatric neurology referral.
Growth and nutritionHeight + weight centile chart; food diary if restrictedAnnual (6 monthly if restricted food repertoire)Falling centiles → dietitian referral; investigate GI comorbidity; review medication impact on appetite.
Clinical scenarioActionKey principle
Behaviour change in non-verbal autistic childInvestigate physical cause first: constipation, ear infection, dental pain, GERD, UTINever attribute behaviour change to autism alone before excluding physical pain
New staring spells or unusual movementsUrgent EEG + paediatric neurology1 in 3 autistic people develop epilepsy — do not attribute seizures to autism behaviour
Developmental regression at any ageUrgent paediatric assessment + EEG; exclude Rett, Landau-Kleffner, metabolicRegression is never "normal autism" — always investigate
School exclusion or school refusalAdvocate letter; SENCO involvement; EHCP if not in place; CAMHS assessmentExclusion is disproportionate in autism; GP advocacy is clinically appropriate
Transition to adult services (age 14–18)EHCP must include transition plan by age 14; adult social care assessment; CAMHS to AMHS handoverTransition planning begins at 14 — not 17. Early planning prevents crisis at 18.
7J — Safety-netting

⚠ Three scenario-specific safety-net phrases

🔴 Developmental regression — any age
"If you ever notice Ethan losing skills he already has — words he used to say, social responses he used to make, things he could do before — I want you to contact us within 48 hours, not wait for your next appointment. Losing skills that were already present is a specific pattern that needs urgent medical investigation. It is not a normal part of autism that we would accept without looking into."
Developmental regression may indicate Rett syndrome, epileptic encephalopathy, or metabolic conditions requiring urgent neurological investigation. "Wait and see" for regression is clinically dangerous and medico-legally indefensible.
🔴 New seizures — any episode
"About one in three autistic children develop epilepsy at some point. If Ethan has any episode that looks like: blank staring lasting more than 30 seconds, his body jerking or convulsing, or a sudden fall — please call 999 for any convulsion lasting more than 5 minutes, or contact us urgently for any suspected seizure. Do not assume unusual behaviour is just autism."
1 in 3 autistic people develop epilepsy. Parents of autistic children commonly attribute staring spells, automatisms, and absence seizures to autism behaviour rather than seizure activity — delaying diagnosis and potentially life-changing antiepileptic treatment.
🟠 Behaviour change = physical pain first
"If Ethan's behaviour suddenly changes — becomes more distressed, more aggressive, more self-injurious — I want you to think about pain before anything else. Children with autism often cannot tell us when they are in pain, so they show us through their behaviour. Constipation, toothache, earache, or a stomach upset can all look like a behaviour problem. Come and see us before changing any behaviour plan."
Physical pain in non-verbal autistic children is systematically undertreated because pain is attributed to autism behaviour. This results in preventable suffering and iatrogenic escalation of behaviour management plans that do not address the underlying cause.
6–8 WeeksReferral acknowledged; audiology booked; SALT started; sleep plan; parental PHQ-9; school SENCO contacted
3–6 MonthsEHCP progressing; SEND Support Plan; CAMHS if escalating; melatonin review; family wellbeing
AnnualGrowth; sleep; GI; epilepsy surveillance; ADHD; family wellbeing; transition planning from age 14
🎓 SCA Checkpoint — Step 7 (Final)TasksRelating to OthersGlobal Skills
Closing the consultation
"Today I am making three referrals: autism assessment, audiology, and speech therapy. These all happen at the same time — you do not wait for one before the others start."
"The waiting time for the autism assessment will likely be 12–18 months. I know that is hard. But the referral today starts the clock on Ethan's educational support, and there is a great deal we can do during that time."
"There is one specific pattern I want you to look out for: if Ethan loses any skills he already has — words he can say now, things he can do — contact us within 48 hours. That is the one situation that needs urgent medical attention."
"There are no medications for autism itself. If sleep is a significant problem, we can discuss a medication that is specifically licensed to help with sleep in autism once we have tried a bedtime routine programme."
"How are you both doing? I would like to give you a brief questionnaire about mood — the period before a diagnosis often carries the most stress. Is there anything else before we finish?"
Deductions — closing
  • "Wait and see" given — prohibited by NICE CG128/CG170
  • Audiology not arranged concurrently with autism referral
  • Antipsychotic initiated in primary care for autism
  • Parental mental health not addressed (PHQ-9 not offered)
  • Regression safety-net absent
  • NAS resources and EHCP information not provided
  • Waiting time not disclosed honestly
Tasks — full criteria
  • Both DSM-5 domains screened; referral made today
  • Audiology concurrent — not deferred
  • No "wait and see" — clear referral decision stated
  • Regression safety-net given verbally
  • No antipsychotics initiated in primary care for core autism
Relating to Others — full criteria
  • Parents validated explicitly ("you are not overreacting")
  • Grandparents' position addressed without dismissing their role
  • Labelling concern corrected with evidence
  • Waiting time honest but hope maintained
  • Parental PHQ-9 offered; parental wellbeing named
  • NAS resources; EHCP explained; closing question asked
🔴 Red
"Wait and see"; Domain B not screened; audiology not arranged; parents dismissed; antipsychotic initiated; regression safety-net absent; parental mental health not addressed; grandparents' view reinforced
🟠 Amber
Referral made but audiology not concurrent; one DSM-5 domain missed; labelling concern not addressed; waiting time not disclosed; parental PHQ-9 not offered; NAS not mentioned
🟢 Green
Both DSM-5 domains; no wait-and-see; three concurrent referrals made; parents validated; grandparents addressed; labelling corrected; waiting time disclosed honestly; regression safety-net; parental PHQ-9; NAS + EHCP information; closing question
Autism in Children — SCA Consultation Scorecard
NICE CG128/CG170 (2022) · DSM-5 · RAG self-assessment · Both domains + no wait-and-see + concurrent audiology
0/ 33 pts
🌐
Global Skills
Structure, language, responsiveness
0/7
Tasks
Clinical reasoning, referral, management
0/15
🤝
Relating to Others
Communication, rapport, shared decision making
0/11
RAG Self-Assessment Guide
🔴 Red
"Wait and see" given; Domain B not screened; audiology not arranged; parents dismissed; antipsychotic initiated; regression safety-net absent; parental mental health not addressed; grandparents' view reinforced
🟠 Amber
Referral made but audiology not concurrent; one DSM-5 domain missed; labelling concern not addressed; waiting time not disclosed; parental PHQ-9 not offered; NAS and EHCP information not given; regression safety-net vague
🟢 Green
Both DSM-5 domains; no wait-and-see; three concurrent referrals; parents validated; grandparents addressed sensitively; labelling reframed; waiting time honest; regression safety-net specific; parental PHQ-9; NAS + EHCP; waiting period made purposeful; closing question
011172533
Fail
Borderline
Pass
Strong pass
📋
Complete the checklist above to see your score interpretation and feedback
"We are here about our son Ethan — he is three and a half. We have been worried about him for a while but my in-laws keep saying he is just a late talker. He only has about 10 or 15 words, he does not put them together, and he has to have everything exactly the same way or he has a complete meltdown."
Who you are

Luke Fletcher (35, accountant) and Jasmine Fletcher (33, part-time teacher, currently on maternity leave with their second child — a 4-month-old daughter). Ethan is their first child, aged 3 years 6 months. They have been noticing the communication differences since about 18 months but have been repeatedly reassured — by Luke's parents ("all boys talk late"), by the health visitor at the 2-year check ("he'll catch up"), and, by reading online, they are now fairly certain this is autism. They feel guilty for considering this. They are exhausted: Ethan sleeps 11pm–4am and has screaming episodes of up to 2 hours. The new baby has significantly increased stress. The nursery SENCO has also expressed concerns recently.

Hidden agenda

Layer 1 — Grandparents: Luke's parents are adamant: "He is fine — Einstein didn't talk until he was 4." They are coming to visit next weekend. Jasmine is dreading it. She needs the GP to validate their concerns authoritatively so she can show Luke's parents that this is a legitimate medical concern, not overprotective parenting. The phrase "as a doctor, I share your concern and I am making this referral today" is exactly what she needs to hear.

Layer 2 — Labelling fear: Both parents are frightened of giving Ethan a "label." They have heard that once a child is labelled autistic, teachers have lower expectations. Jasmine particularly worries about this, having seen how labelled children are treated in her school. This fear must be directly addressed — not dismissed — for the parents to fully engage with the referral.

Clinical details if asked
  • Vocabulary: 10–15 single words (mama, dada, car, more, no, ta, ball, juice, bye-bye, up, and 5–6 others); no two-word combinations; some echolalia from TV ("the wiggles", "ready steady go")
  • Pointing: points to request (reaches towards things he wants); does NOT point to share interest ("look at that bird!") — this detail only revealed if specifically asked
  • Social: plays alongside children but not with them; interested in Luke and Jasmine; not interested in their new baby or other children; rarely initiates social games; does not respond to name consistently (about 50% of the time)
  • Domain B features: exact same route to nursery every time (screaming if different); exact same 3 books in exact order at bedtime; lines up toy cars precisely; colour-specific plate; refuses all foods except 6–8 items; intensely fascinated with wheels (could watch them spin for an hour)
  • Sleep: falls asleep at 11pm; wakes at 4am; will not go back to sleep; no nap; total sleep 5 hours; Luke and Jasmine each averaging 4 hours
  • Regression: no — skills have been slow to develop but not lost
  • Seizures: no
Reactions to key moments
  • When candidate screens for regression: "No — he hasn't lost anything he had before. Things have just been slow." (Reassured — this is the correct safety-net question.)
  • When "wait and see" is offered: Jasmine becomes visibly upset — "That is what everyone has told us for 18 months. Can't you just tell us if he needs help or not?" (This scenario must be avoided.)
  • When three concurrent referrals are made: Visible relief — "Finally. Thank you. Can I show my in-laws this letter?"
  • Challenge line: "My mother-in-law says we should just do more speech therapy and he will catch up. Do you think she might be right? Is it possible this is just a speech delay?"
"My mother-in-law says we should just be doing more speech therapy and that autism is a fashionable diagnosis that gets given to perfectly normal children who are just a bit different. Could she be right? Could this just be a speech delay that will catch up?"

Resolution: Luke and Jasmine will be fully satisfied and reassured if the candidate: (1) explicitly validates their concerns and does NOT give "wait and see"; (2) identifies both DSM-5 domains without leading the parents; (3) makes three concurrent referrals (autism assessment, audiology, SALT) today; (4) addresses the labelling concern with specific practical examples of what the diagnosis unlocks (EHCP, DLA, school support); (5) answers the challenge line by explaining that speech delay alone does not cause insistence on sameness, rigid routines, and absent joint attention — these are the two separate diagnostic domains that together warrant assessment; (6) offers PHQ-9 to both parents and provides NAS resources before they leave. They will disengage if they leave without a referral, without the waiting time being disclosed, or without the labelling concern being addressed.

🏥
Clinic Quick Reference
Autism in Children — Clinical Decision Framework
NICE CG128/CG170 (2022) · DSM-5 · CKS Autism 2023 · NICE BNFc
expand
🚦 1 — Triage Algorithm
Child with developmental concerns → screen for regression and seizures FIRST → then DSM-5 domain assessment
🔴 Urgent (<2 weeks)
  • Developmental regression (loss of skills): urgent paediatrics + EEG
  • New seizures: urgent EEG + paediatric neurology
  • Stereotyped hand movements in girl with regression: Rett syndrome — urgent genetics + neurology
  • Parental mental health crisis affecting child safety: MASH + adult mental health
Regression: never "wait and see" — urgent EEG
🟠 Urgent (weeks)
  • Suspected autism with school entry <12 months: urgent referral + EHCP now
  • Severe sleep disorder: Slenyto while awaiting assessment
  • No words at 24 months / no two-word phrases at 30 months: urgent SALT + paediatrics
School entry <12 months: urgent + EHCP simultaneously
🟢 Routine
  • Suspected autism — both domains present: autism assessment referral + audiology + SALT (all concurrent)
  • No "wait and see": NICE CG128/CG170 mandates referral if autism suspected
Three concurrent referrals: autism + audiology + SALT
🔬 2 — DSM-5 Domains and Key Numbers
DSM-5 — Both Domains Required for Diagnosis
Domain A — Social Communication Deficits: Social-emotional reciprocity; non-verbal communicative behaviours (pointing, eye contact, gestures); developing / maintaining / understanding relationships — across multiple contexts
Domain B — Restricted/Repetitive Behaviours (≥2): Stereotyped movements; insistence on sameness / inflexibility; highly restricted / fixated interests; hyper- or hypo-sensitivity to sensory input
Early Red Flags
No babbling → 12 months: urgent referral
No pointing to share interest → 14 months: referral indicated
No single words → 16 months: urgent referral
No two-word phrases → 24 months: urgent referral
Regression at any age: urgent paediatrics + EEG
Stereotyped hand movements (girls): Rett syndrome → genetics
Eye contact does NOT exclude autism
NEVER
"Wait and see" — NICE CG128/CG170 mandates referral if autism suspected
Concurrent
Autism assessment + audiology + SALT — all three at same time
48 hours
Regression of any skill → contact within 48h; not routine appointment
20 weeks
EHCP process maximum — start before school entry at age 5
4.6 years
Girls diagnosed later than boys — masking/camouflaging
80%
Autistic children with sleep difficulties — Slenyto (licensed; BNFc)
50–70%
Autism + ADHD comorbidity rate
1 in 3
Autistic people who develop epilepsy — surveillance at every review
⚠ 3 — Safety-Netting, Monitoring and Red Flags
🔴 Regression (loss of skills)
"Contact us within 48 hours if Ethan loses any skills he already has. This needs urgent investigation, not a routine appointment."
🔴 New seizures
"1 in 3 autistic people develop epilepsy. Any blank staring >30 seconds, body jerking, or sudden fall = urgent EEG. Do not attribute to autism."
🟠 Behaviour change
"Any sudden behaviour change = investigate physical pain first (constipation, ear, teeth, GERD) before attributing to autism."
Follow-up timeline
6w
6–8 weeks: Referral progress; audiology; SALT; sleep; PHQ-9
3m
3–6 months: EHCP; SEND Plan; CAMHS if escalating; melatonin review
Dx
Post-diagnosis: NAS Earlybird; DLA; EHCP; comorbidity review
1yr
Annual: Growth; sleep; GI; epilepsy; ADHD; family wellbeing
📌 NEVER antipsychotics for core autism features in primary care
🚨 Urgent referral flags: Regression → 48h paediatrics + EEG · New seizures → urgent EEG + neurology · Stereotyped hand wringing in girl → Rett syndrome genetics · Macrocephaly → PTEN screen · Parental mental health crisis → MASH if child safety at risk
🛡️ Safety rules: NEVER "wait and see" · NEVER antipsychotics for core autism in primary care · NEVER audiology deferred before autism referral · Regression = never "autism variant" without EEG · GI pain first before escalating behaviour plans · Melatonin (Slenyto) after 3 months sleep hygiene · EHCP application before school entry
🎓
SCA Exam Quick Reference
Autism in Children SCA — DSM-5 + No Wait-and-See + Three Referrals
Tasks · Relating to Others · Global Skills
expand
🕐 12-Minute Consultation Flow
0–2 min
Open Question + Regression Screen
"Thank you for coming in — I can hear this has been worrying you for a while. Before I ask anything specific, I want to hear from you: tell me about Ethan — what is he like at home, what does he enjoy, and what has made you concerned?"
Regression screen early: "Has he ever lost skills he had before — words or things he could do?" Listen for both DSM-5 domains spontaneously before asking targeted questions.
TasksRelating to OthersGlobal Skills
✗ Starting with "does he make eye contact?" · ✗ Leading the diagnostic history before open narrative · ✗ Missing Domain B by focusing only on language
2–5 min
Domain A + Domain B + Hearing + ICE
"Does he point to things to show you — not to ask for things, but just because he wants to share something exciting with you?"
"Are there things that have to be done exactly the same way every time — a specific route, specific words, specific order?"
ICE: "What do you think might be happening?" / "What worries you most?" / "What were you hoping we could do today?" Hearing screen: "Has he had a formal hearing test?"
TasksRelating to Others
✗ Diagnosing or excluding autism based on eye contact · ✗ Accepting neonatal screen as hearing exclusion · ✗ Skipping Domain B
5–7 min
Validate + Challenge "Wait and See"
"I want to say clearly: you are right to be concerned, and you are right to be here. The pattern you are describing — the pointing, the routines, the way Ethan plays — fits with two specific things I want to have properly assessed."
"About the grandparents' view: it comes from a caring place. But a speech delay alone does not cause insistence on exact routines and no interest in sharing with others. These are two separate patterns that together need specialist assessment."
Relating to OthersGlobal Skills
✗ "Let's wait a bit longer and see" · ✗ Reinforcing grandparents' view · ✗ Not addressing the labelling concern before ending
7–10 min
Three Referrals + EHCP + NAS
"I am making three referrals today: the autism assessment team, audiology for a full hearing test, and speech therapy. These all happen at the same time — you do not wait for one before the others."
"I want to address the labelling concern directly. A diagnosis does not create limits — it removes them. Without it, the school cannot access support funding, and you cannot get an EHCP or DLA. The label is the key that unlocks support."
TasksRelating to Others
✗ Single referral without audiology and SALT · ✗ Not discussing EHCP and school timing · ✗ Not providing NAS resources
10–12 min
Safety-Net + Parental Wellbeing + Close
"If Ethan loses any skills he already has — contact us within 48 hours. That is the one pattern that needs urgent investigation, not a routine appointment."
"How are you both doing? The period before a diagnosis is often the hardest. I would like to give you a brief questionnaire — and here is the National Autistic Society website for families at exactly this stage."
TasksGlobal Skills
✗ No regression safety-net · ✗ No parental PHQ-9 · ✗ No NAS resources · ✗ No closing question
🔴🟠🟢 RAG — All 3 Domains
Tasks
🟢
Both DSM-5 domains screened; no wait-and-see; autism + audiology + SALT concurrent; regression safety-net specific and verbal; no antipsychotics in primary care; EHCP timing explained; parental PHQ-9; NAS resources; 6–8-week follow-up named
🟠
Referral made but audiology not concurrent; one domain missed; regression safety-net vague; EHCP not mentioned; parental wellbeing not addressed; NAS not given; follow-up appointment not named
🔴
"Wait and see"; Domain B not screened; audiology not arranged; parents dismissed; antipsychotic initiated; regression safety-net absent; grandparents' view reinforced
Relating to Others
🟢
Parents validated explicitly; grandparents addressed sensitively without dismissal; labelling concern reframed with practical examples; waiting time honest; waiting period made purposeful; ICE all three elements; parental wellbeing named; hopeful prognosis; closing question
🟠
ICE partial; labelling concern noted but not reframed; grandparents mentioned but not addressed; waiting time not disclosed; prognosis not given; parental wellbeing not addressed
🔴
Grandparents' view reinforced; labelling fear worsened; no ICE; parents dismissed; no parental wellbeing; no closing question
Global Skills
🟢
Open question first; both domains revealed by narrative; plain language; chunk-and-check; parental expertise validated; prognosis hopeful and accurate; closing question; consultation structured in 12 minutes
🟠
Adequate structure but leading questions used; plain language mostly but jargon in places; chunk-and-check absent; consultation ran over without completing plan
🔴
Leading questions; eye contact used to dismiss autism; paternalistic tone; parents talked at not with; no validation; prognosis catastrophised
💬 Key Phrases
💭 Validate parental expertise
"You are right to be here. You are not overreacting. The pattern you are describing fits with two specific developmental patterns I take seriously, and I am making the referral today."
😟 Address the labelling fear
"A diagnosis does not create limits — it removes them. Without it, the school cannot access the funding he needs, you cannot apply for an EHCP, and you cannot claim DLA. The diagnosis is the key that unlocks support."
🎯 Address grandparents' view
"A speech delay alone does not cause insistence on the exact same route and the exact same routines. These are two separate patterns that together need specialist assessment — this is not overprotection."
🔬 Honest waiting time
"The waiting time for the full assessment is 12–18 months. I know that is hard. But the referral starting today is still important — and there is a great deal we can do during that time."
📋 Regression safety-net
"If Ethan loses any skill he already has — words, social responses, anything — contact us within 48 hours. That specific pattern needs urgent investigation, not a routine appointment."
💚 Parental wellbeing
"How are you both doing through all of this? This period — before you have any answers — is often the hardest. I want to make sure you are getting support too, not just Ethan."
🚫 8 Danger Zones
"Wait and see"→ NICE CG128/CG170 explicitly prohibits deferring referral. "Wait and see" is the single most common harmful response to parental autism concerns. Document that you did NOT give this advice.
Domain B not screened→ Both DSM-5 domains are required for diagnosis. A candidate who screens only Domain A (language, eye contact) and misses Domain B (insistence on sameness, restricted interests, sensory sensitivities) has an incomplete clinical picture.
Audiology not concurrent→ Formal audiology is a mandatory component of the NICE CG128/CG170 pathway. Accepting the neonatal hearing screen as sufficient is incorrect. Audiology must be arranged alongside — not before or instead of — the autism referral.
Eye contact used to dismiss autism→ Autistic children often make good eye contact with familiar people. The presence of eye contact does not exclude autism. This is the most common clinical error in GP autism consultations.
Regression safety-net absent→ Developmental regression may indicate Rett syndrome, epileptic encephalopathy, or metabolic conditions. Every autism consultation must end with explicit instructions to contact within 48 hours for any loss of skills.
Antipsychotic initiated in primary care for autism→ NICE CG128/CG170 prohibits antipsychotics for core autism features. Specialist-initiated only, for specific challenging behaviour causing harm, after all behavioural interventions exhausted. Never in primary care without specialist recommendation.
Labelling concern dismissed or ignored→ The fear of "labelling" is the most common barrier to parental engagement with the autism assessment process. It must be addressed directly with specific practical examples of what the diagnosis unlocks (EHCP, DLA, school funding, services).
Parental mental health not addressed→ PHQ-9 at every autism consultation. Parental depression in the context of an undiagnosed autistic child is both common and a child safeguarding concern. Offering support to the parents is part of the child's healthcare, not a separate issue.
💊 Drug Quick-Pick by Scenario
Sleep disturbance (autism)
Slenyto 1–5mg ON
NICE BNFc; licensed autism sleep age 2–18; after 3m sleep hygiene
ADHD comorbidity (no anxiety)
Methylphenidate (slow titration)
Specialist-initiated; may worsen anxiety/stereotypies in autism
ADHD + autism + anxiety
Atomoxetine (preferred)
Non-stimulant; does not worsen anxiety; takes 4–6 weeks
Anxiety comorbidity
Autism-adapted CBT first
SSRIs only with specialist guidance; behavioural activation risk higher in autism
Constipation / GI pain
Movicol Paediatric Plain
1 sachet/year of age; behaviour change = check pain first
Challenging behaviour
SPECIALIST ONLY
Aripiprazole/Risperidone — never GP-initiated; not for core autism; full metabolic monitoring
⛔ NO medications for core autism features · NEVER antipsychotics in primary care for autism · Slenyto only after 3-month sleep hygiene programme · Methylphenidate may worsen anxiety/stereotypies in autism — monitor closely · SSRIs: behavioural activation risk higher in autism — start at half standard dose with specialist oversight · Never "wait and see" · Behaviour change = physical pain first · Regression = urgent EEG + paediatrics
Reviewed: July 2026 · citations verified against current NICE / UK guidance