Kidney Failure Risk Equation (KFRE, 4-variable)
2- and 5-year risk of kidney failure needing dialysis or transplant, from age, sex, eGFR and urine ACR.
What it is for
Adults with CKD G3a–G5 (eGFR < 60). NICE NG203 (2021) uses the 4-variable KFRE 5-year risk as one of its referral criteria. The non-North American calibration used by UK laboratories is applied here.
Use the working calculator
The working Kidney Failure Risk Equation (KFRE, 4-variable) calculator is on our calculators page. It is free and needs no account. Enter the values and it shows the result with the reading that goes with it.
The calculators are free. The trial opens the protocols and pathways they link to.What you enter
The calculator asks for 4 items.
- Age (yrs)
- SexOptions: Male; Female
- eGFR (CKD-EPI) (mL/min/1.73m²)
- Urine albumin:creatinine ratio (ACR) (mg/mmol)Use mg/mmol as reported by UK laboratories.
How the result is read
The result is shown as Kidney failure risk. Formula: Risk = 1 − S₀^exp(−0.2201×(age/10 − 7.036) + 0.2467×(male − 0.5642) − 0.5567×(eGFR/5 − 7.222) + 0.4510×(ln ACR[mg/g] − 5.137)); S₀ = 0.9832 (2 years), 0.9365 (5 years), non-North American calibration; ACR mg/g = mg/mmol × 8.84.
Sources
These are the sources the calculator cites. Check the current version before relying on a threshold.
Related
For qualified clinicians. A score supports a clinical decision and does not make it: check the inputs, read the cited source, and use the tools in your clinical system for patient care where one is provided.